Hazard review of alpha-naphthylamine (1-NA) (1-naphthylamine).

Details

• Personal Author:
  Lassiter DV
• Description:
  The toxic hazards of exposure to alpha-naphthylamine (134327) (1-NA) are discussed. Its use in the manufacture of azo dyes and in the rubber industry is noted, and the phenomenon of aniline cancer is described. The concentration of beta-naphthylamine (91598) (2-NA) found in industrial 1-NA is discussed. The results of 1-NA carcinogenicity tests in rabbits, rats, dogs, mice, and hamsters are summarized, along with species differences in 1-NA metabolism. The relative carcinogenicity of N-hydroxylated derivatives of naphthylamines is reviewed, including tumor induction rates for 1- naphthylhydroxylamine (607307) and 2-naphthylhydroxylamine (613478). The carcinogenic potentials of the 1 nitroso and 2 nitroso compounds of 1-NA and 2-NA are compared. Findings from several epidemiological surveys of workers exposed to 1-NA are discussed, including occurrences of sessile papillomas and bladder tumors in relation to duration and degree of exposure. The possible interaction between 1-NA and 2-NA in inducing bladder tumors is considered. The mutagenicity of the N-hydroxylated derivatives is described along with the relationship between carcinogenicity and mutagenicity. The author notes that the contamination of 1-NA by 2- NA precludes a direct evaluation of the carcinogenicity of 1-NA alone. Both compounds yield metabolites that have been determined to be proximate carcinogens; however, the ultimate carcinogenic metabolite remains unknown. 1-NA should be considered a human carcinogen until evidence to the contrary is established.
• Subjects:
  Accident Prevention Accidents Accidents, Occupational Occupational Health Personal Protective Equipment Protective Clothing Safety
• Keywords:
  Animal-studies Carcinogens Comparative-toxicology Disease-incidence Dyes Employee-exposure Health-hazards Industrial-chemicals NIOSH-Author Rubber-manufacturing
• Document Type:
  Text
• Genre:
  Other
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ORSD - Office of Research and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-12
• NIOSHTIC Number:
  nn:00135951
• Citation:
  NIOSH 1973 Jun; :1-12
• CAS Registry Number:
  1-Naphthylamine (CAS RN 134-32-7) ; 2-Naphthylamine (CAS RN 91-59-8) ; N-Hydroxy-1-naphthalenamine (CAS RN 607-30-7) ; N-Hydroxy-2-naphthalenamine (CAS RN 613-47-8)
• Federal Fiscal Year:
  1973
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5fa62b7e6be4064a49e037210d350d0d23f1a23324090721779297abea0e5d8c094c625eda226de6073e7d4bd729d5d32ba7fee788575aca6004c8771d6926b1
• Download URL:
  https://stacks.cdc.gov/view/cdc/179675/cdc_179675_DS1.pdf
• File Type:
  [PDF - 363.62 KB ]