Health effects of occupational exposure to carbon disulfide.

Details

• Personal Author:
  Albright BE ; Burg, Jeanne R. ; Fajen J ; Johnson BL ; Lee, Shio T. ; Leffingwell S ; Meyer, Channing R. ; Putz-Anderson, Vernon ; Smith, Alexander B.
• Description:
  A survey of workers exposed to carbon-disulfide (75150) (CS2) at concentrations below the current standard of 20 parts per million (ppm) was conducted. The cohort consisted of 146 male workers at a rayon staple factory (SIC-2823). The comparison group consisted of 233 workers at the same facility having no CS2 exposure. The average ages of the cohort and comparisons were 38.2 and 33.9 years, respectively. Subjects were administered comprehensive medical examinations that included neurological, endocrine, metabolic, reproductive, and cardiovascular evaluations. Industrial hygiene sampling for CS2 was performed. CS2 concentrations ranged from 0.58 to 12.64ppm. Exposed workers showed very little increased morbidity, but exposure dependent increases in pathological changes such as increased frequency of angina and myocardial infarction, systolic and diastolic blood velocity, increased symptoms of muscular weakness, increased low density of lipoproteins, increased fasting blood sugar, increased proportion of abnormal sperm forms, and increased incidence of retinal abnormalities. The authors conclude that the present standard of 20ppm leaves little margin of safety. Additional research on the cardiovascular toxicity of CS2 and review of the current standard are recommended.
• Subjects:
  Accidents, Occupational Health Care Facilities Workforce And Services Manufacturing And Industrial Facilities Occupational Health Preceptorship Radiation Radio Waves Safety Staff Development Surveys And Questionnaires Workplace

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• Keywords:
  Carbamates Cardiovascular-system Chronic-exposure Exposure-limits NIOSH-Author Poisons Sulfides Synthetic-fibers-industry Toxic-dose Toxic-effects
• Document Type:
  Text
• Genre:
  Other
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-201
• NIOSHTIC Number:
  nn:00135185
• Citation:
  NIOSH 1984 May; :1-201
• CAS Registry Number:
  Carbon disulfide (CAS RN 75-15-0)
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  False
• NAICS and SIC Codes:
  2823 - Cellulomanmade fibers - (SIC)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1103aa2b211a34b5cf843de526d9ab4f2253f800593e9666a417f82879989e1c5fde19287503d8984e1b811e5e5dd3ae3cdf543d7165d92fc9b27a68efe3f7bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/179667/cdc_179667_DS1.pdf
• File Type:
  [PDF - 6.70 MB ]