Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, methyl bromide.

Details

• Personal Author:
  McGregor DB
• Description:
  Methyl-bromide (74839) was subjected to a tier II mutagenic test screening program. Screening included the following assays: unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours and concentrations up to 70 percent in air; dominant lethal test in male rats and sperm abnormality tests in male mice with exposure to atmospheres containing 20 to 70 parts per million (ppm) methyl-bromide; cytogenetic test in male and female rats with bone marrow cells; and sex linked recessive lethal test in Drosophila-melanogaster with exposure to atmospheres of 20 or 70ppm for 5 hours. There was no increase in UDS in cells treated with methyl-bromide nor was the frequency of aberrant cells increased. There were no effects attributable to methyl-bromide in the dominant lethal test on pregnancy frequency, numbers of corpora lutea graviditatis or implantations, or the frequency of early deaths. Sperm abnormality frequency was not affected and sex linked recessive lethal mutation frequency was not increased as a result of methyl-bromide exposure. The author concludes that methyl-bromide was devoid of genetic effects.
• Subjects:
  Accidents, Occupational Chemistry Chemistry, Analytic Chromatography Ethylenes Occupational Health Safety
• Keywords:
  Bioassays Biochemical-tests Contract-210-78-0026 Genetic-disorders Mutagenesis NIOSH-Contract Toxicology
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-181
• NIOSHTIC Number:
  nn:00123526
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1981 May; :1-181
• CAS Registry Number:
  Methyl bromide (CAS RN 74-83-9)
• Federal Fiscal Year:
  1981
• Performing Organization:
  Inveresk Research International Limited, Musselburgh, Scotland
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6e3958837d073bb4fe33fd2f53eef000990e8bf4fbcb103d5e456877d980a25b4c5bcc5234d1379851e5dbee9b8ce0fc15a0d665d9ad14b3a97ea82384b99707
• Download URL:
  https://stacks.cdc.gov/view/cdc/179485/cdc_179485_DS1.pdf
• File Type:
  [PDF - 4.69 MB ]