Mortality study of workers employed at organochlorine pesticide manufacturing plants.

Details

• Personal Author:
  Brown DP ; Ditraglia D ; Iverson N ; Namekata T
• Description:
  Mortality of workers employed in the manufacture of chlorinated hydrocarbon pesticides was studied. A retrospective cohort study involving a total of 2100 persons who had been employed for at least 6 months prior to January, 1964, was conducted in four manufacturing facilities producing chlordane (57749), heptachlor (76448), dichlorodiphenyltrichloroethane (50293) (DDT), or aldrin (309002), dieldrin (60571), and endrin (72208). Vital status of 90 to 97 percent of study cohort members as of December 31, 1976, was determined. Cause of death for all known dead was determined from death certificates. Expected cause specific mortality rates were calculated using a modified life table analysis program and comparison with observed deaths. The standardized mortality ratio (SMR) for all causes of death in each cohort was below expected, ranging from 66 to 82. SMRs ranged from 68 to 91 for all malignant neoplasms and from 55 to 132 for respiratory cancer. The chlordane factory had a slight excess of stomach cancer deaths. The aldrin, dieldrin, and endrin facility had an excess of esophagus, rectum, liver, and lymphatic and hematopoietic system cancers and a higher than expected incidence of pneumonia and other respiratory diseases. The authors conclude that the number of workers involved and number of deaths that occurred are too small to make any valid associations between cause specific mortality and employment at the pesticide factories.
• Subjects:
  Accidents, Occupational Biochemistry Ergonomics Occupational Health Safety Surveys And Questionnaires
• Keywords:
  Carcinogenesis Chemical-industry-workers Chemical-manufacturing-industry Epidemiology Humans Mortality-rates Pesticides-and-agricultural-chemicals
• Publisher:
  NCI; EPA; NIOSH
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  District of Columbia ; Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  206-228
• NIOSHTIC Number:
  nn:00123096
• Citation:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland. Kraybill HF, Blackwood IC, Freas NB, eds. Washington, DC: National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health, 1980 May; :206-228
• CAS Registry Number:
  1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene (CAS RN 57-74-9) ; Heptachlor (CAS RN 76-44-8) ; DDT (CAS RN 50-29-3) ; Aldrin (CAS RN 309-00-2) ; Dieldrin (CAS RN 60-57-1) ; Endrin (CAS RN 72-20-8)
• Editor(s):
  Kraybill HF ; Blackwood IC ; Freas NB
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:92de4ace66d2cfc6eb8b7c882c749564b396dc5583bcb064bba82b5ec39927d7ba70c5477b4f344ad2b2c33d3a13c09db1133e1d444e3c02de97236204b89fbe
• Download URL:
  https://stacks.cdc.gov/view/cdc/179471/cdc_179471_DS1.pdf
• File Type:
  [PDF - 425.89 KB ]