Studies of organ-associated antigens and other markers in human tumors which may be useful for the diagnosis of malignant diseases.

Details

• Personal Author:
  Herberman R
• Description:
  Ongoing studies to develop immunologic or other diagnostic markers as cancer screening tests are described. A test for leukemias and lymphomas involved preparation of heterologous antisera, primarily in rabbits, that reacted against antigens associated with different types of human leukemias. Attempts to improve specificity and develop large amounts of reagents have involved the production of monoclonal antibodies in mice to detect various series of antigens. A second research project involved a marker called EDCI, a low molecular weight protein found in the urine of cancer patients, which was considered potentially useful in screening for breast cancer. Problems in improving the sensitivity and specificity of the EDCI test are discussed. The author concludes that the tests described have potential use in screening for leukemia and breast cancer, with possibilities for other types of cancer as well.
• Subjects:
  Accidents, Occupational Biological Products Biological Warfare Agents Environmental Exposure Environmental Pollution Hazardous Substances Microbiology Occupational Health Safety
• Keywords:
  Biochemical-tests Carcinogenesis Diagnostic-techniques Diagnostic-tests Immunology Medical-monitoring Medical-screening
• Publisher:
  NCI; EPA; NIOSH
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  District of Columbia ; Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  327-332
• NIOSHTIC Number:
  nn:00123090
• Citation:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland. Kraybill HF, Blackwood IC, Freas NB, eds. Washington, DC: National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health, 1980 May; :327-332
• Editor(s):
  Kraybill HF ; Blackwood IC ; Freas NB
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:08412236ad0328581819d1551de19d05fc2f050ef43d5b99eb52de301b821589ef2648b2581bcdc89462919e1653d4766bbbf1af4ab5c457873b282b4054d1cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/179465/cdc_179465_DS1.pdf
• File Type:
  [PDF - 438.81 KB ]