Chronic animal inhalation study of short (5 micrometers) asbestos fibers.

Details

• Personal Author:
  Groth DH ; Platek SF
• Description:
  The chronic effects of inhalation of short chrysotile asbestos (1332214) fibers were studied in rats and monkeys. Sprague-Dawley- rats and cynomolgus-monkeys were exposed in an inhalation chamber for 7 hours a day, 5 days a week, for 18 months to less than 1 milligram asbestos fiber per cubic meter of air. The ratio of the number of fibers less than 5 microns in length to the number greater than 5 microns was 265 to 1. Rats were killed at 1, 3, 6, 12, and 18 months after exposure began, and tissues were examined histopathologically and by scanning electron and light microscopy. Lung tissue showed little or no reaction to inhaled asbestos. Light microscopy did not reveal asbestos fibers in lung tissues, but electron microscopy detected fibers in alveolar macrophages. No tissue tests had been conducted on monkeys at the time of this report since none had been sacrificed or had died.
• Subjects:
  Accidents, Occupational Air Pollutants, Occupational Animals Carcinogens Environmental Exposure Metal Workers Mortality Occupational Health Particulate Matter Safety Silicon Dioxide

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• Keywords:
  Asbestos-dust Dust-exposure Dust-inhalation Fibrous-bodies Histology Laboratory-animals Pulmonary-system-disorders
• Publisher:
  NCI; EPA; NIOSH
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  District of Columbia ; Maryland ; Michigan ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  447-469
• NIOSHTIC Number:
  nn:00123088
• Citation:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland. Kraybill HF, Blackwood IC, Freas NB, eds. Washington, DC: National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health, 1980 May; :447-469
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Editor(s):
  Kraybill HF ; Blackwood IC ; Freas NB
• Federal Fiscal Year:
  1980
• Performing Organization:
  International Research and Development Corporation, Mattawan, Michigan 49071
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2fe6ffe9b812ecc49172573b1c5758e4c061cca969ef6b05282f06a6abee77fca214a44fb240111c81e2e10f9bcbc8daf3bce3c2473bfb8d002c486f344fc67
• Download URL:
  https://stacks.cdc.gov/view/cdc/179463/cdc_179463_DS1.pdf
• File Type:
  [PDF - 781.03 KB ]