Neuropathological evaluation of monkeys exposed to ethylene and propylene oxide.

Details

• Personal Author:
  Carter J ; Matzke H ; Sprinz H
• Description:
  The neuropathological effect of ethylene-oxide (75218) and propylene- oxide (75569) on monkeys was studied. Male monkeys were exposed to and 300ppm propylene-oxide at 6 hours per day, 5 days per week for 2 years. Brain, ulnar and sciatic nerves, and spinal cord tissue were examined histologically. No differences were found between controls and chemically treated animals, between sciatic and ulnar nerves, and between different levels of these nerves. The eight segments of spinal cord of control and experimental animals had no specific pathological differences. In the medulla oblongata of the brain, ethylene-oxide and propylene-oxide exposed monkeys had signs of axonal distrophy. Ethylene-oxide exposed monkeys also had signs of demyelination in this area of the brain. The author concludes that the concern expressed by OSHA about the allowable maximal amount of ethylene-oxide is strengthened by the result of the present study. Also, in view of the current great interest in the effect of chronic occupational exposure to the two compounds, additional studies would seem justified.
• Subjects:
  Accidents, Occupational Hazardous Substances Hydrogen Sulfide Occupational Health Oil And Gas Industry Personal Protective Equipment Safety Safety Management
• Keywords:
  Central-nervous-system Comparative-toxicology Contract-210-81-6004 Nervous-system-disorders Neurotoxicity NIOSH-Contract Oxides
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Missouri ; Ohio ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:00122451
• Citation:
  NIOSH 1982 Feb; :1-9
• CAS Registry Number:
  Ethylene oxide (CAS RN 75-21-8) ; (±)-Propylene oxide (CAS RN 75-56-9)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  Midwest Research Institute, Kansas City, Missouri, NIOSH, Cincinnati, Ohio, 9 pages, 10 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7ce000884f5a6ee4d7e6ba157966052cb97f09408ecd36bc2bbf12e203d22900ee1941be578191224b7cd3533c9d1cf472164c33756ec569d1bc02b1416fd418
• Download URL:
  https://stacks.cdc.gov/view/cdc/179435/cdc_179435_DS1.pdf
• File Type:
  [PDF - 651.95 KB ]