Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, 2-methoxyethanol.

Details

• Personal Author:
  McGregor D
• Description:
  The Tier II mutagenic screening of 2-methoxyethanol (109864) is discussed. The properties, human exposure and toxicology of the compound are reviewed. The chemicals, animals, animal management and atmosphere generation, are described. The methods for DNA synthesis assay, cytogenetic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality analysis, sex linked recessive lethal test and statistical evaluation are discussed. Results of these analyses are presented. The author concludes that 2-methoxyethanol has a profound effect upon male fertility but does not induce chromosomal aberrations in rat bone marrow. Also, it is recommended that more detailed studies of the effects upon testicular cells be conducted to reach an understanding of the dominant lethal test and sperm abnormality test results.
• Subjects:
  Accidents, Occupational Coal Coal Mining Laboratories Mining Occupational Health Safety Vehicle Emissions
• Keywords:
  Bioassays Comparative-toxicology Contract-210-78-0026 Medical-research Medical-screening Mutagenesis NIOSH-Contract Screening-methods
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-227
• NIOSHTIC Number:
  nn:00122313
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1980 Nov; :1-227
• CAS Registry Number:
  2-Methoxyethanol (CAS RN 109-86-4)
• Federal Fiscal Year:
  1981
• Performing Organization:
  Inveresk Research International Limited, Musselburgh, Scotland
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d9dc2f8b22f412b096832610d7c37a821499502263008a2b81b755f816211a28f23afaa02ceeec1f021fff59d3ed2e48739877d9bc29f2bdd47df5db8c61e773
• Download URL:
  https://stacks.cdc.gov/view/cdc/179428/cdc_179428_DS1.pdf
• File Type:
  [PDF - 8.29 MB ]