Tier II mutagenic screening of 13 NIOSH priority compounds, individual compound report, N-methyl dicyclohexylamine.

Details

• Personal Author:
  McGregor D
• Description:
  The Tier II mutagenic screening of N-methyl-dicyclohexylamine (7560830) is studied. The structure and toxicology of the compound is presented. The chemicals, animals, animal management and atmosphere generation involved with the studies are described. The methods for DNA synthesis assay, cytogenic analysis of rat bone marrow cells, dominant lethal testing, sperm abnormality tests in Drosophila melanogaster and statistical evaluation are discussed. The results of these analyses are presented. The author concludes that N-methyl-dicyclohexylamine has genotoxic properties and can not induce unscheduled DNA synthesis in cultured mammalian cells.
• Subjects:
  Accidents, Occupational Aerosols Microbiology Occupational Health Safety Silicon Dioxide Software Talc
• Keywords:
  Analytical-methods Bioassays Contract-210-78-0026 Medical-screening Mutagenesis NIOSH-Contract Screening-methods
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-203
• NIOSHTIC Number:
  nn:00122312
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1981 Jun; :1-203
• CAS Registry Number:
  Methyldicyclohexylamine (CAS RN 7560-83-0)
• Federal Fiscal Year:
  1981
• Performing Organization:
  Inveresk Research International Limited, Musselburgh, Scotland
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8f6381af36aba101dbf1d2d299d209d5bb71a1815bf6fe36090e82d990862bada08fad30212e25adbbc3a443b1ae7260610832580d4a58ff35dffcd697c1968f
• Download URL:
  https://stacks.cdc.gov/view/cdc/179427/cdc_179427_DS1.pdf
• File Type:
  [PDF - 4.91 MB ]