Tropheryma whipplei in Patients with Pneumonia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bousbia, Sabri ; Papazian, Laurent ; Auffray, Jean-Pierre ; Fenollar, Florence ; Martin, Claude ; Li, Wenjun ; Chiche, Laurent ; La Scola, Bernard ; Raoult, Didier
• Description:
  Tropheryma whipplei is the etiologic pathogenic agent of Whipple disease (WD), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. PCR-based methods for diagnosis of WD have been developed. T. whipplei has been identified in saliva and stool samples from patients with WD and from healthy persons. T. whipplei DNA has also been found in bronchoalveolar lavage (BAL) samples of a child with pneumonia. We detected DNA of T. whipplei in 6 (3%) of 210 BAL samples collected in intensive care units by using 16S rDNA and specific quantitative PCR. We identified 4 novel genotypes of T. whipplei. In 1 case, T. whipplei was the only bacterium; in 4 others, it was associated with buccal flora. We suggest that T. whipplei should be investigated as an etiologic agent of pneumonia.
• Subjects:
  Actinomycetales Infections Adolescent Adult Aged Aged, 80 And Over Bacteria Bronchoalveolar Lavage Fluid Community-Acquired Infections Genotyping Humans Intensive Care Units Male Middle Aged Pneumonia, Bacterial Polymerase Chain Reaction Population Surveillance Research Saliva Tropheryma Tropheryma Whipplei Ventilator-associated Pneumonia Whipple Disease Whipple Disease Diagnosis Young Adult

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• Source:
  Emerg Infect Dis. 16(2):258-263.
• Document Type:
  Journal Article
• Volume:
  16
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:bd2350d78e546c61ee5f29a5991519bc9b6c234cff17553769b26c940726cfa6
• Download URL:
  https://stacks.cdc.gov/view/cdc/17929/cdc_17929_DS1.pdf
• File Type:
  [PDF - 143.34 KB ]