Chloroprene: adverse effects on reproduction.

Details

• Personal Author:
  Infante PF
• Description:
  Studies on the reproductive effects of chloroprene (126998) are reviewed. Information is provided on the mutagenicity and carcinogenicity of the chemical reproductive studies in laboratory animals and epidemiological surveys of exposed worker populations are discussed together with the incidence of chloroprene induced chromosomal abnormalities. The author concludes that chloroprene is a potential human mutagen, and recommends several areas of future research such as evaluation of the dominant lethal test, the effects of chloroprene metabolites and the determination of the optimum level of significance for chromosomal aberration tests.
• Subjects:
  Accidents, Occupational Chemistry, Analytic Chromatography Occupational Health Safety
• Keywords:
  Butadienes Carcinogens Chromosome-damage Epidemiology Laboratory-animals Metabolites Occupational-exposure Reproductive-effects Toxic-effects Workers
• Document Type:
  Text
• Genre:
  Conference/Symposia Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  87-101
• NIOSHTIC Number:
  nn:00105771
• Citation:
  NIOSH 1980 Oct:87-101
• CAS Registry Number:
  Chloroprene (CAS RN 126-99-8)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e9956dc59493f30fb5b2c7c2e998ffb5f8af86d1afaeb6bf7d3634fd5d1dc71f9f360a8f41f7bd421edd441c550eb3d23a20d7e451f52a7d8279ad4253815a55
• Download URL:
  https://stacks.cdc.gov/view/cdc/178997/cdc_178997_DS1.pdf
• File Type:
  [PDF - 477.03 KB ]