Urinary metabolites from controlled exposures of humans to trichloroethylene.

Details

• Personal Author:
  Dodd HC ; Hake CL ; Peterson JE ; Stewart RD
• Description:
  The urinary metabolites of trichloroethylene (79016) (TCE), trichloroethanol (115208), and trichloroacetic-acid (76039), were measured after humans had been exposed for controlled periods of time to either 20, 100 or 200ppm of TCE vapor for 5 days per week. The quantity and concentration of each metabolite varied widely during the daily exposures of identical magnitudes. If the excretion of either of these metabolites, or their sum, is to be considered as a measure of exposure, it must be remembered that at the current TLV, and at higher exposures, both the concentration and quantity are affected by previous recent exposures. At the lowest level of exposure studied the effect was lessened, indicating a better clearance of the metabolites on a daily basis. It is the conclusion that the measurement of urinary metabolites is not an ideal method of predicting the magnitude of a human exposure to the vapors of TCE, particularly if the exposure was near or greater than the current TLV.
• Subjects:
  Accident Prevention Accidents Accidents, Occupational Construction Industry Electric Injuries Electricity Environmental Monitoring Laboratories Occupational Exposure Occupational Health Occupational Injuries Personal Protective Equipment Safety

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• Keywords:
  Acetic-acids Chlorinated-hydrocarbons Contract-099-72-0084 Medical-monitoring Metabolic-products Monitoring-systems NIOSH-Contract Organic-solvents Solvents Urinalysis Urine-chemistry

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• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-24
• NIOSHTIC Number:
  nn:00080951
• Citation:
  NIOSH 1973 May; :1-24
• CAS Registry Number:
  Trichloroethylene (CAS RN 79-01-6) ; Trichloroethanol (CAS RN 115-20-8) ; Trichloroacetic acid (CAS RN 76-03-9)
• Federal Fiscal Year:
  1973
• Performing Organization:
  The Medical College of Wisconsin, Department of Environmental Medicine
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c22ae1aacc4b8398458cd687f5a2500767e693eaa74f7f32027e6baa782dd240866f5323eeeebd96995e45cc07dff4b971e8fa4269a446a7674ba5fce5b232a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/178893/cdc_178893_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]