Nontuberculous Mycobacteria Infections and Anti–Tumor Necrosis Factor-α Therapy

Winthrop, Kevin L.; Chang, Eric; Yamashita, Shellie; Iademarco, Michael F.; LoBue, Philip A.

doi:10.3201/eid1510.090310

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Nontuberculous Mycobacteria Infections and Anti–Tumor Necrosis Factor-α Therapy

Published Date:

Oct 2009

Publisher's site:

http://dx.doi.org/10.3201/eid1510.090310 New Site Icon

Source:

Emerg Infect Dis. 15(10):1556-1561.

[PDF-425.15 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Winthrop, Kevin L. ; Chang, Eric ; Yamashita, Shellie ; Iademarco, Michael F. ; LoBue, Philip A. ;

Description:

Patients receiving anti-tumor necrosis factor-alpha (anti-TNF-alpha) therapy are at increased risk for tuberculosis and other granulomatous diseases, but little is known about illness caused by nontuberculous mycobacteria (NTM) in this setting. We reviewed the US Food and Drug Administration MedWatch database for reports of NTM disease in patients receiving anti-TNF-alpha therapy. Of 239 reports collected, 105 (44%) met NTM disease criteria. Median age was 62 years; the majority of patients (66, 65%) were female, and most (73, 70%) had rheumatoid arthritis. NTM infections were associated with infliximab (n = 73), etanercept (n = 25), and adalimumab (n = 7); most patients were taking prednisone (n = 68, 65%) or methotrexate (n = 58, 55%) concurrently. Mycobacteria avium (n = 52, 50%) was most commonly implicated, and 9 patients (9%) had died at the time their infections were reported. A high rate of extrapulmonary manifestations (n = 46, 44%) was also reported.

Subject:

[+]

Pubmed ID:

19861045

Pubmed Central ID:

PMC2866401

Document Type:

Journal Article

Funding:

1K08HS017552-01/HS/AHRQ HHS/United States

Collection(s):

Emerging Infectious Diseases
CDC Public Access

Main Document Checksum:

[+]

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