Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis

Details

• Alternative Title:
  Immunol Infect Dis
• Personal Author:
  Williamson, Dhelia M. ; Marrie, Ruth Ann ; Ashley-Koch, Allison ; Satten, Glen A.
• Description:
  This study was conducted to determine whether single nucleotide polymorphisms (SNPs) in nine genes (human leukocyte antigen (|), T cell receptor beta (|), tumor necrosis factor α (|), tumor necrosis factor β (|), apolipoprotein E (|), interleukin 7 receptor alpha chain (|) interleukin 2 receptor alpha chain (|) myelin basic protein (|) and vitamin D receptor (|)) associated with multiple sclerosis (MS) could be replicated in a population-based sample, and to determine if these associations are modified by presence of |*|. DNA was available from 722 individuals (223 with MS and 499 controls) who participated in a population-based case-control study. Cases and controls were matched on ancestry, age, gender and geographic area. |*| risk allele (T) was confirmed in this population using a genotypic test, controlling for multiple comparisons. Examining the effect of each SNP in the presence or absence of the |*| risk allele identified significant associations with | (rs1799964) among those without the HLA risk allele. No additional interactions were significant in a cases-only analysis. Our results indicate that an interaction between SNPs in TNF α and HLA DRB1*1501 may influence the risk of developing MS.
• Keywords:
  A-DRB1*1501 Case-Control Study Genetic Susceptibility Gene–Gene Interaction Multiple Sclerosis Tumor Necrosis Factor-Alpha
• Source:
  Immunol Infect Dis. 2013; 1(1):10-17
• Pubmed ID:
  25741530
• Pubmed Central ID:
  PMC4328031
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  1
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6a2a45df471274a85453ac74b5ba06f2085b139a337a9b4ae701f9e3facbb9fc
• Download URL:
  https://stacks.cdc.gov/view/cdc/30290/cdc_30290_DS1.pdf
• File Type:
  [PDF - 328.35 KB ]