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Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis
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9 2013
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Source: Immunol Infect Dis. 2013; 1(1):10-17
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Alternative Title:Immunol Infect Dis
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Description:This study was conducted to determine whether single nucleotide polymorphisms (SNPs) in nine genes (human leukocyte antigen (|), T cell receptor beta (|), tumor necrosis factor α (|), tumor necrosis factor β (|), apolipoprotein E (|), interleukin 7 receptor alpha chain (|) interleukin 2 receptor alpha chain (|) myelin basic protein (|) and vitamin D receptor (|)) associated with multiple sclerosis (MS) could be replicated in a population-based sample, and to determine if these associations are modified by presence of |*|. DNA was available from 722 individuals (223 with MS and 499 controls) who participated in a population-based case-control study. Cases and controls were matched on ancestry, age, gender and geographic area. |*| risk allele (T) was confirmed in this population using a genotypic test, controlling for multiple comparisons. Examining the effect of each SNP in the presence or absence of the |*| risk allele identified significant associations with | (rs1799964) among those without the HLA risk allele. No additional interactions were significant in a cases-only analysis. Our results indicate that an interaction between SNPs in TNF α and HLA DRB1*1501 may influence the risk of developing MS.
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Pubmed ID:25741530
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Pubmed Central ID:PMC4328031
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