Invasive Haemophilus influenzae Disease, Europe, 1996–2006

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ladhani, Shamez ; Slack, Mary P.E. ; Heath, Paul T. ; von Gottberg, Anne ; Chandra, Manosree ; Ramsay, Mary E.
• Corporate Authors:
  European Union Invasive Bacterial Infection Surveillance participants
• Description:
  An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality.
• Subjects:
  Adolescent Adult Aged Child Child, Preschool Female Haemophilus Infections Haemophilus Influenzae Type B Haemophilus Vaccines Humans Immunization Programs Incidence Infant Male Middle Aged National Health Programs Population Surveillance Vaccines, Conjugate Young Adult

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• Source:
  Emerg Infect Dis. 16(3):455-463.
• Document Type:
  Journal Article
• Place as Subject:
  Europe
• Volume:
  16
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1469b6589561710664a303e93a392a10b7b7ea7c292173c2bcf10e5293972610
• Download URL:
  https://stacks.cdc.gov/view/cdc/17867/cdc_17867_DS1.pdf
• File Type:
  [PDF - 162.30 KB ]