Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Ladhani, Shamez ; Slack, Mary P.E. ; Heath, Paul T. ; von Gottberg, Anne ; Chandra, Manosree ; ... More +
Ladhani, Shamez ; Slack, Mary P.E. ; Heath, Paul T. ; von Gottberg, Anne ; Chandra, Manosree ; Ramsay, Mary E. Less -
Corporate Authors:
European Union Invasive Bacterial Infection Surveillance participants
Description:
An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality.
Subject:
[+]
Adolescent
Adult
Aged
Child
Child, Preschool
Female
Haemophilus Infections
Haemophilus Influenzae Type B
Haemophilus Vaccines
Humans
Immunization Programs
Incidence
Infant
Male
Middle Aged
National Health Programs
Population Surveillance
Vaccines, Conjugate
Young Adult

Source:
Emerg Infect Dis. 16(3):455-463.
Document Type:
Journal Article
Place as Subject:
Europe
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:1469b6589561710664a303e93a392a10b7b7ea7c292173c2bcf10e5293972610
File Type:

Supporting Files

• 	09-0290-F.gif	gif
  	09-0290-F.jpg	jpeg
  	09-0290_finalR.nxml	txt
  	license.txt	txt

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