Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Dean, Deborah ; Bruno, William J. ; Wan, Raymond ; Gomes, João P. ; Devignot, Stéphanie ; ... More +
Dean, Deborah ; Bruno, William J. ; Wan, Raymond ; Gomes, João P. ; Devignot, Stéphanie ; Mehari, Tigist ; de Vries, Henry J.C. ; Morré, Servaas A. ; Myers, Garry ; Read, Timothy D. ; Spratt, Brian G. Less -
Description:
Chlamydia trachomatis is a global cause of blinding trachoma and sexually transmitted infections (STIs). We used comparative genomics of the family Chlamydiaceae to select conserved housekeeping genes for C. trachomatis multilocus sequencing, characterizing 19 reference and 68 clinical isolates from 6 continental/subcontinental regions. There were 44 sequence types (ST). Identical STs for STI isolates were recovered from different regions, whereas STs for trachoma isolates were restricted by continent. Twenty-nine of 52 alleles had nonuniform distributions of frequencies across regions (p<0.001). Phylogenetic analysis showed 3 disease clusters: invasive lymphogranuloma venereum strains, globally prevalent noninvasive STI strains (ompA genotypes D/Da, E, and F), and nonprevalent STI strains with a trachoma subcluster. Recombinant strains were observed among STI clusters. Single nucleotide polymorphisms (SNPs) were predictive of disease specificity. Multilocus and SNP typing can now be used to detect diverse and emerging C. trachomatis strains for epidemiologic and evolutionary studies of trachoma and STI populations worldwide.
Subjects:
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Bacteria Bacterial Proteins Bacterial Sequence Typing Bacterial Typing Techniques Chlamydia Infections Chlamydia Trachomatis Communicable Diseases, Emerging DNA, Bacterial Genomics Humans Lymphogranuloma Venereum Phenotype Phylogeny Polymorphism, Single Nucleotide Predictive Value Of Tests Recombination, Genetic Research Sequence Analysis, DNA Sexually Transmitted Diseases Sexually Transmitted Infections Single Nucleotide Polymorphisms Species Specificity Trachoma
Source:
Emerg Infect Dis. 15(9):1385-1394.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:4a390e8339ab3b72b7552377b2420925d27fb6b82727859102062c1f437ea789
Download URL:
https://stacks.cdc.gov/view/cdc/17864/cdc_17864_DS1.pdf
File Type:

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