Epidemiology of Hepatitis A Virus Infections, Germany, 2007–2008

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Faber, Mirko S. ; Stark, Klaus ; Behnke, Susanne C. ; Schreier, Eckart ; Frank, Christina
• Description:
  Approximately 60% of hepatitis A virus infections in Germany occur in persons without a travel history to disease-endemic areas and for whom sources of infection are unknown. Recommendation of pretravel vaccination fails to prevent the remaining imported infections. Using enhanced surveillance in 2007-2008, we analyzed epidemiologic patterns of hepatitis A in Germany and appropriateness and adequacy of current immunization recommendations. Young patients with a migration background who had visited friends and family in their ancestral countries accounted for most imported cases. Phylogenetic analysis showed high diversity of sequence data and clustering of strains with similar regions of origin or patient migration backgrounds. Virologic findings are compatible with those of low-incidence countries, where virtually all infections are directly or indirectly imported from other regions. Germans with a migration background are seen as a special risk group so far insufficiently reached by pretravel vaccination advice.
• Subjects:
  Adolescent Adult Aged Base Sequence Child Child, Preschool DNA, Viral DNA Primers Emigrants And Immigrants Emigration And Immigration Female Hepatitis A Hepatitis A Virus Humans Infant Male Middle Aged Molecular Epidemiology Phylogeny Risk Factors Rna, Viral Travel Young Adult

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• Source:
  Emerg Infect Dis. 15(11):1760-1768.
• Document Type:
  Journal Article
• Place as Subject:
  Germany
• Volume:
  15
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:47f32a39f69d7e430c06fb2bf3393cfa236eb6882c86c3a810a06e50454fc99d
• Download URL:
  https://stacks.cdc.gov/view/cdc/17854/cdc_17854_DS1.pdf
• File Type:
  [PDF - 328.64 KB ]