Healthcare Worker Occupation and Immune Response to Pneumocystis jirovecii

Tipirneni, Renuka; Daly, Kieran R.; Jarlsberg, Leah G.; Koch, Judy V.; Swartzman, Alexandra; Roth, Brenna M.; Walzer, Peter D.; Huang, Laurence

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Healthcare Worker Occupation and Immune Response to Pneumocystis jirovecii

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Oct 2009
By Tipirneni, Renuka ; Daly, Kieran R. ; Jarlsberg, Leah G. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Tipirneni, Renuka ; Daly, Kieran R. ; Jarlsberg, Leah G. ; Koch, Judy V. ; Swartzman, Alexandra ; Roth, Brenna M. ; Walzer, Peter D. ; Huang, Laurence
Description:

The reservoir and mode of transmission of Pneumocystis jirovecii remain uncertain. We conducted a cross-sectional study of 126 San Francisco General Hospital staff in clinical (n = 103) and nonclinical (n = 23) occupations to assess whether occupational exposure was associated with immune responses to P. jirovecii. We examined antibody levels by ELISA for 3 overlapping fragments that span the P. jirovecii major surface glycoprotein (Msg): MsgA, MsgB, and MsgC1. Clinical occupation participants had higher geometric mean antibody levels to MsgC1 than did nonclinical occupation participants (21.1 vs. 8.2, p = 0.004); clinical occupation was an independent predictor of higher MsgC1 antibody levels (parameter estimate = 0.89, 95% confidence interval 0.29-1.48, p = 0.003). In contrast, occupation was not significantly associated with antibody responses to either MsgA or MsgB. Healthcare workers may have occupational exposure to P. jirovecii. Humans may be a reservoir for P. jirovecii and may transmit it from person to person.
Subjects:

Adult Aged Aged, 80 And Over Antibodies Antibodies, Fungal Cross-Sectional Studies Female Fungal Fungal Proteins Fungi Health Personnel HIV/AIDS And Other Retroviruses Humans Male Middle Aged Occupational Exposure Opportunistic Infections Pneumocystis Pneumocystis Infections Pneumocystis Jirovecii Questionnaires Research Serologic Tests Young Adult
Source:

Emerg Infect Dis. 15(10):1590-1597.
Document Type:

Journal Article
Volume:

15
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:af3edd4394c745728c7a5a962284301ce63119801999c38575841472caeb124b
Download URL:

https://stacks.cdc.gov/view/cdc/17850/cdc_17850_DS1.pdf
File Type:

[PDF - 515.79 KB ]

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