Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ayelet, Gelagay ; Mahapatra, Mana ; Gelaye, Esayas ; Egziabher, Berhe G. ; Rufeal, Tesfaye ; Sahle, Mesfin ; Ferris, Nigel P. ; Wadsworth, Jemma ; Hutchings, Geoffrey H. ; Knowles, Nick J.
• Description:
  Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981-2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent.
• Subjects:
  Animals Cattle Cattle Diseases Cell Line Cricetinae Disease Outbreaks Foot-and-Mouth Disease Foot-and-Mouth Disease Virus Genetic Variation Goat Diseases Goats Molecular Sequence Data Phylogeny Research Sequence Analysis, DNA Serotyping Sheep Sheep Diseases

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• Source:
  Emerg Infect Dis. 15(9):1409-1417.
• Document Type:
  Journal Article
• Place as Subject:
  Ethiopia
• Location:
  Africa
• Volume:
  15
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0b4ec2a0d165c25ea5fa32e4d2e9d2337cd3bf8f4d0bddc77bacab6b3e307a8b
• Download URL:
  https://stacks.cdc.gov/view/cdc/17823/cdc_17823_DS1.pdf
• File Type:
  [PDF - 679.22 KB ]