Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Krauland, Mary G. ; Marsh, Jane W. ; Paterson, David L. ; Harrison, Lee H.
Krauland, Mary G. ; Marsh, Jane W. ; Paterson, David L. ; Harrison, Lee H. Less -
Description:
Salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons. Clonal expansion and horizontal gene transfer may contribute to the spread of antimicrobial drug-resistance integrons in these organisms. We investigated this resistance and integron carriage among 90 isolates with the ACSSuT phenotype (resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline) in a global collection of S. enterica isolates. Four integrons, dfrA12/orfF/aadA2, dfrA1/aadA1, dfrA7, and arr2/blaOXA30/cmlA5/aadA2, were found in genetically unrelated isolates from 8 countries on 4 continents, which supports a role for horizontal gene transfer in the global dissemination of S. enterica multidrug resistance. Serovar Typhimurium isolates containing identical integrons with the gene cassettes blaPSE1 and aadA2 were found in 4 countries on 3 continents, which supports the role of clonal expansion. This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica.
Subject:
[+]
Anti-Bacterial Agents
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
Gene Transfer, Horizontal
Global Health
Humans
Integrons
Microbial Sensitivity Tests
Polymerase Chain Reaction
Research
Salmonella Infections
Salmonella Typhimurium
Sequence Analysis, DNA
Serotyping

Source:
Emerg Infect Dis. 15(3):388-396.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:684ee39037ba714d391ff282b9f9ca46e4f2dee67af037d726140c1c8dc50c9e
File Type:

Supporting Files

• 	08-1131-F.gif	gif
  	08-1131-F.jpg	jpeg
  	08-1131_appT-s1.pdf	pdf
  	08-1131_finalR.nxml	txt
  	license.txt	txt

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