Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1112.050158
Personal Author:
Wedel, Stephanie D. ; Bender, Jeffrey B. ; Leano, Fe T. ; Boxrud, David J. ; Hedberg, Craig ; ... More +
Wedel, Stephanie D. ; Bender, Jeffrey B. ; Leano, Fe T. ; Boxrud, David J. ; Hedberg, Craig ; Smith, Kirk E. Less -
Description:
We compared antimicrobial resistance phenotypes and pulsed-field gel electrophoresis (PFGE) subtypes of 1,028 human and 716 animal Salmonella enterica serotype Typhimurium isolates from Minnesota from 1997 to 2003. Overall, 29% of human isolates were multidrug resistant. Predominant phenotypes included resistance to ampicillin, chloramphenicol or kanamycin, streptomycin, sulfisoxazole, and tetracycline (ACSSuT or AKSSuT). Most human multidrug-resistant isolates belonged to PFGE clonal group A, characterized by ACSSuT resistance (64%), or clonal group B, characterized by AKSSuT resistance (19%). Most animal isolates were from cattle (n = 358) or swine (n = 251). Eighty-one percent were multidrug resistant; of these, 54% were at least resistance phenotype ACSSuT, and 43% were at least AKSSuT. More than 80% of multidrug-resistant isolates had a clonal group A or B subtype. Resistance to ceftriaxone and nalidixic acid increased, primarily among clonal group A/ACSSuT isolates. Clonal group B/AKSSuT isolates decreased over time. These data support the hypothesis that food animals are the primary reservoir of multidrug-resistant S. Typhimurium.
Subject:
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Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Research
Salmonella Infections
Salmonella Infections, Animal
Salmonella Typhimurium
Time Factors

Source:
Emerg Infect Dis. 11(12):1899-1906.
Document Type:
Journal Article
Funding:
U50/CCU511190-10/CC/ODCDC CDC HHS/United States ; U50/CCU519683-04-4/CC/ODCDC CDC HHS/United States
U50/CCU511190-10/CC/ODCDC CDC HHS/United States ; U50/CCU519683-04-4/CC/ODCDC CDC HHS/United States Less -
Place as Subject:
Minnesota
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:70c0e975d6d028c785b0d744579c902c95742e6aae9f98c759535780bb3fa6fe
File Type:

Supporting Files

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