Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Takahashi, Kazuaki ; Okamoto, Hiroaki ; Abe, Natsumi ; Kawakami, Manri ; Matsuda, Hiroyuki ; ... More +
Takahashi, Kazuaki ; Okamoto, Hiroaki ; Abe, Natsumi ; Kawakami, Manri ; Matsuda, Hiroyuki ; Mochida, Satoshi ; Sakugawa, Hiroshi ; Suginoshita, Yoshiki ; Watanabe, Seishiro ; Yamamoto, Kazuhide ; Miyakawa, Yuzo ; Mishiro, Shunji Less -
Description:
Hepatitis E virus (HEV) genotype 3, which usually causes asymptomatic infection in Japan, induced severe hepatitis in 8 patients. To better understand genetic features of HEV associated with increased virulence, we determined the complete or near-complete nucleotide sequences of HEV from these 8 patients and from 5 swine infected with genotype 3 strain swJ19. Phylogenetic analysis showed that the isolates from the 8 patients and the 5 swine grouped separately from the other genotype 3 isolates to create a unique cluster, designated JIO. The human JIO-related viruses encoded 18 amino acids different from those of the other HEV genotype 3 strains. One substitution common to almost all human HEV strains in the JIO cluster was located in the helicase domain (V239A) and may be associated with increased virulence. A zoonotic origin of JIO-related viruses is suspected because the isolates from the 5 swine also possessed the signature V239A substitution in helicase.
Subject:
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Aged Amino Acid Sequence Animals Female Genotype Hepatitis, Viral, Animal Hepatitis E Hepatitis E Virus Humans Male Middle Aged Molecular Sequence Data Phylogeny Sequence Analysis, DNA Swine Swine Diseases Virulence
Source:
Emerg Infect Dis. 15(5):704-709.
Document Type:
Journal Article
Place as Subject:
Japan
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d78751e0e45848f8d3877def72160210d00cd733cd456030336095da897cf33b
Download URL:
https://stacks.cdc.gov/view/cdc/17719/cdc_17719_DS1.pdf
File Type:

Supporting Files

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