Virulent Strain of Hepatitis E Virus Genotype 3, Japan

Takahashi, Kazuaki; Okamoto, Hiroaki; Abe, Natsumi; Kawakami, Manri; Matsuda, Hiroyuki; Mochida, Satoshi; Sakugawa, Hiroshi; Suginoshita, Yoshiki; Watanabe, Seishiro; Yamamoto, Kazuhide; Miyakawa, Yuzo; Mishiro, Shunji

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Virulent Strain of Hepatitis E Virus Genotype 3, Japan

Published Date:

May 2009

Source:

Emerg Infect Dis. 15(5):704-709.

[PDF-310.80 KB]

Details:

Personal Authors:

Takahashi, Kazuaki ; Okamoto, Hiroaki ; Abe, Natsumi ; Kawakami, Manri ; Matsuda, Hiroyuki ; ... More ▼

Keywords:

[+]

Description:

Hepatitis E virus (HEV) genotype 3, which usually causes asymptomatic infection in Japan, induced severe hepatitis in 8 patients. To better understand genetic features of HEV associated with increased virulence, we determined the complete or near-complete nucleotide sequences of HEV from these 8 patients and from 5 swine infected with genotype 3 strain swJ19. Phylogenetic analysis showed that the isolates from the 8 patients and the 5 swine grouped separately from the other genotype 3 isolates to create a unique cluster, designated JIO. The human JIO-related viruses encoded 18 amino acids different from those of the other HEV genotype 3 strains. One substitution common to almost all human HEV strains in the JIO cluster was located in the helicase domain (V239A) and may be associated with increased virulence. A zoonotic origin of JIO-related viruses is suspected because the isolates from the 5 swine also possessed the signature V239A substitution in helicase.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	license.txt	text/plain
	08-1100-F1.gif	image/gif
	08-1100-F1.jpg	image/jpeg
	08-1100-F2.gif	image/gif
	08-1100-F2.jpg	image/jpeg
	08-1100_app-s1.gif	image/gif
	08-1100_finalR.nxml	text/plain

No Related Documents.

You May Also Like:

Sources of Hepatitis E Virus Genotype 3 in the Netherlands

Personal Author:

Rutjes, Saskia A.; Lodder, Willemijn J.; Lodder-Verschoor, Froukje; van den Berg, Harold H.J.L.; Vennema, Harry; Duizer, Erwin; Koopmans, Marion; de Roda Husman, Ana Maria;

Published:

Mar 2009

Source:

Emerg Infect Dis. 15(3):381-387.

Description:

Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied. HEV genotype 3/op...

File Type:

[PDF - 207.00 KB]
Hepatitis E Virus Genotype Diversity in Eastern China

Personal Author:

Zhang, Wen; He, Yilin; Wang, Hua; Shen, Quan; Cui, Li; Wang, Xiaochun; Shao, Shihe; Hua, Xiuguo;

Published:

Oct 2010

Source:

Emerg Infect Dis. 16(10):1630-1632.

Description:

We studied 47 hepatitis E virus (HEV) isolates from hospitalized patients in Nanjing and Taizhou, eastern China. Genotypes 1, 3, and 4 were prevalent; genotype 3 and subgenotype 4b showed a close relationship with the swine strains in eastern China, ...

File Type:

[PDF - 239.62 KB]
Hepatitis E Epidemic, Biratnagar, Nepal, 2014

Personal Author:

Shrestha, Ananta; Lama, Thupten K.; Karki, Sneha; Sigdel, Deepak R.; Rai, Utsav; Rauniyar, Shyam K.; Al-Mahtab, Mamun; Takahashi, Kazuaki; Arai, Masahiro; Akbar, Sheikh M.F.; Mishiro, Shunji;

Published:

Apr 2015

Source:

Emerg Infect Dis. 21(4):711-713.

File Type:

[PDF - 668.00 KB]
African Swine Fever Virus in Pork Brought into South Korea by Travelers from China, August 2018

Personal Author:

Kim, Hyun-Joo; Lee, Min-Jung; Lee, Soo-Kyoung; Kim, Da-young; Seo, Sang-Ji; Kang, Hae-Eun; Nam, Hyang-Mi;

Published:

June 17 2019

Source:

Emerg Infect Dis. 25(6):1231-1233

Description:

We tested samples of pork products confiscated from travelers to South Korea for African swine fever virus (ASFV). We detected ASFV in 4 food items confiscated from travelers from Shenyang, China, in August 2018. Surveillance of pork products at coun...

File Type:

[PDF - 545.93 KB]
Accuracy of Diagnostic Methods and Surveillance Sensitivity for Human Enterovirus, South Korea, 1999–2011

Personal Author:

Hyeon, Ji-Yeon; Hwang, Seoyeon; Kim, Hyejin; Song, Jaehyoung; Ahn, Jeongbae; Kang, Byunghak; Kim, Kisoon; Choi, Wooyoung; Chung, Jae Keun; Kim, Cheon-Hyun; Cho, Kyungsoon; Jee, Youngmee; Kim, Jonghyun; Kim, Kisang; Kim, Sun-Hee; Kim, Min-Ji; Cheon, Doo-Sung;

Published:

Aug 2013

Source:

Emerg Infect Dis. 19(8):1268-1275.

Description:

The epidemiology of enteroviral infection in South Korea during 1999-2011 chronicles nationwide outbreaks and changing detection and subtyping methods used over the 13-year period. Of 14,657 patients whose samples were tested, 4,762 (32.5%) samples w...

File Type:

[PDF - 546.22 KB]