Virulent Strain of Hepatitis E Virus Genotype 3, Japan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Takahashi, Kazuaki ; Okamoto, Hiroaki ; Abe, Natsumi ; Kawakami, Manri ; Matsuda, Hiroyuki ; Mochida, Satoshi ; Sakugawa, Hiroshi ; Suginoshita, Yoshiki ; Watanabe, Seishiro ; Yamamoto, Kazuhide ; Miyakawa, Yuzo ; Mishiro, Shunji
• Description:
  Hepatitis E virus (HEV) genotype 3, which usually causes asymptomatic infection in Japan, induced severe hepatitis in 8 patients. To better understand genetic features of HEV associated with increased virulence, we determined the complete or near-complete nucleotide sequences of HEV from these 8 patients and from 5 swine infected with genotype 3 strain swJ19. Phylogenetic analysis showed that the isolates from the 8 patients and the 5 swine grouped separately from the other genotype 3 isolates to create a unique cluster, designated JIO. The human JIO-related viruses encoded 18 amino acids different from those of the other HEV genotype 3 strains. One substitution common to almost all human HEV strains in the JIO cluster was located in the helicase domain (V239A) and may be associated with increased virulence. A zoonotic origin of JIO-related viruses is suspected because the isolates from the 5 swine also possessed the signature V239A substitution in helicase.
• Subjects:
  Aged Amino Acid Sequence Animals Female Genotype Hepatitis, Viral, Animal Hepatitis E Hepatitis E Virus Humans Male Middle Aged Molecular Sequence Data Phylogeny Sequence Analysis, DNA Swine Swine Diseases Virulence

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• Source:
  Emerg Infect Dis. 15(5):704-709.
• Document Type:
  Journal Article
• Place as Subject:
  Japan
• Location:
  Asia
• Volume:
  15
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d78751e0e45848f8d3877def72160210d00cd733cd456030336095da897cf33b
• Download URL:
  https://stacks.cdc.gov/view/cdc/17719/cdc_17719_DS1.pdf
• File Type:
  [PDF - 310.80 KB ]