Virulent Strain of Hepatitis E Virus Genotype 3, Japan

Takahashi, Kazuaki; Okamoto, Hiroaki; Abe, Natsumi; Kawakami, Manri; Matsuda, Hiroyuki; Mochida, Satoshi; Sakugawa, Hiroshi; Suginoshita, Yoshiki; Watanabe, Seishiro; Yamamoto, Kazuhide; Miyakawa, Yuzo; Mishiro, Shunji

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Virulent Strain of Hepatitis E Virus Genotype 3, Japan

Published Date:

May 2009

Source:

Emerg Infect Dis. 15(5):704-709.

[PDF-310.80 KB]

Details:

Personal Authors:

Takahashi, Kazuaki ; Okamoto, Hiroaki ; Abe, Natsumi ; Kawakami, Manri ; Matsuda, Hiroyuki ; ... More ▼

Keywords:

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Description:

Hepatitis E virus (HEV) genotype 3, which usually causes asymptomatic infection in Japan, induced severe hepatitis in 8 patients. To better understand genetic features of HEV associated with increased virulence, we determined the complete or near-complete nucleotide sequences of HEV from these 8 patients and from 5 swine infected with genotype 3 strain swJ19. Phylogenetic analysis showed that the isolates from the 8 patients and the 5 swine grouped separately from the other genotype 3 isolates to create a unique cluster, designated JIO. The human JIO-related viruses encoded 18 amino acids different from those of the other HEV genotype 3 strains. One substitution common to almost all human HEV strains in the JIO cluster was located in the helicase domain (V239A) and may be associated with increased virulence. A zoonotic origin of JIO-related viruses is suspected because the isolates from the 5 swine also possessed the signature V239A substitution in helicase.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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