CTX-M β-Lactamase Production and Virulence of Escherichia coli K1

Dubois, Damien; Prasadarao, Nemani V.; Mittal, Rahul; Bret, Laurent; Roujou-Gris, Marie; Bonnet, Richard

doi:10.3201/eid1512.090928

i

CTX-M β-Lactamase Production and Virulence of Escherichia coli K1

Supporting Files Public Domain

Dec 2009
By Dubois, Damien ; Prasadarao, Nemani V. ; Mittal, Rahul ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Dubois, Damien ; Prasadarao, Nemani V. ; Mittal, Rahul ; Bret, Laurent ; Roujou-Gris, Marie ; Bonnet, Richard
Description:

We report a patient with neonatal meningitis caused by a CTX-M-1-producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in clinical outcome.
Subjects:

Adult Animals Antimicrobial Resistance Bacteria Beta-Lactamases CTX-M Dispatch Escherichia Coli Extended-spectrum β-lactamase Female Humans Infant, Newborn Meningitis Meningitis, Bacterial Mice Neonatal Pregnancy Virulence
Source:

Emerg Infect Dis. 15(12):1988-1990.
Document Type:

Journal Article
Volume:

15
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:c1db8426325757416f96ac61b315e4c5f356c4cb8be9bc9e8f91bb28c617a1c8
Download URL:

https://stacks.cdc.gov/view/cdc/17584/cdc_17584_DS1.pdf
File Type:

[PDF - 182.10 KB ]

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