Possible Interruption of Malaria Transmission, Highland Kenya, 2007–2008

John, Chandy C.; Riedesel, Melissa A.; Magak, Ng’wena G.; Lindblade, Kim A.; Menge, David M.; Hodges, James S.; Vulule, John M.; Akhwale, Willis

doi:10.3201/eid1512.090627

i

Possible Interruption of Malaria Transmission, Highland Kenya, 2007–2008

Supporting Files

Dec 2009
By John, Chandy C. ; Riedesel, Melissa A. ; Magak, Ng’wena G. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

John, Chandy C. ; Riedesel, Melissa A. ; Magak, Ng’wena G. ; Lindblade, Kim A. ; Menge, David M. ; Hodges, James S. ; Vulule, John M. ; Akhwale, Willis
Description:

Highland areas where malaria transmission is unstable are targets for malaria elimination because transmission decreases to low levels during the dry season. In highland areas of Kipsamoite and Kapsisiywa, Kenya (population approximately 7,400 persons), annual household indoor residual spraying with a synthetic pyrethroid was performed starting in 2005, and artemether/lumefantrine was implemented as first-line malaria treatment in October 2006. During April 2007-March 2008, no microscopy-confirmed cases of malaria occurred at the sites. In 4 assessments of asymptomatic persons during May 2007-April 2008, a total of <0.3% of persons were positive for asexual Plasmodium falciparum by microscopy or PCR at any time, and none were positive by PCR at the last 2 sample collections. Our findings show that in such areas, interruption and eventual elimination of malaria transmission may be achievable with widespread annual indoor residual spraying of households and artemisinin combination therapy.
Subjects:

Animals Artemisinins Drug Combinations Ethanolamines Fluorenes Health Policy Humans Insecticides Mosquito Control Parasitemia Polymerase Chain Reaction Rain Research Temperature Time Factors
Source:

Emerg Infect Dis. 15(12):1917-1924.
Document Type:

Journal Article
Funding:

K08 AI01572/AI/NIAID NIH HHS/United States ; U01 AI056270/AI/NIAID NIH HHS/United States
Place as Subject:

Kenya
Location:

Africa
Volume:

15
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:22be45f0b25c4f191db5e439dcd4099c65e67329a6241a12aed03d79e37f5ee3
Download URL:

https://stacks.cdc.gov/view/cdc/17566/cdc_17566_DS1.pdf
File Type:

[PDF - 379.86 KB ]

File Language:

English

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