Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Mooi, Frits R. ; van Loo, Inge H.M. ; van Gent, Marjolein ; He, Qiushui ; Bart, Marieke J. ; ... More +
Mooi, Frits R. ; van Loo, Inge H.M. ; van Gent, Marjolein ; He, Qiushui ; Bart, Marieke J. ; Heuvelman, Kees J. ; de Greeff, Sabine C. ; Diavatopoulos, Dimitri ; Teunis, Peter ; Nagelkerke, Nico ; Mertsola, Jussi Less -
Description:
Before childhood vaccination was introduced in the 1940s, pertussis was a major cause of infant death worldwide. Widespread vaccination of children succeeded in reducing illness and death. In the 1990s, a resurgence of pertussis was observed in a number of countries with highly vaccinated populations, and pertussis has become the most prevalent vaccine-preventable disease in industrialized countries. We present evidence that in the Netherlands the dramatic increase in pertussis is temporally associated with the emergence of Bordetella pertussis strains carrying a novel allele for the pertussis toxin promoter, which confers increased pertussis toxin (Ptx) production. Epidemiologic data suggest that these strains are more virulent in humans. We discuss changes in the ecology of B. pertussis that may have driven this adaptation. Our results underline the importance of Ptx in transmission, suggest that vaccination may select for increased virulence, and indicate ways to control pertussis more effectively.
Subject:
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Adolescent
Alleles
Bacteria
Bacterial Outer Membrane Proteins
Base Sequence
Bordetella Pertussis
Child
Child, Preschool
Communicable Diseases, Emerging
DNA, Bacterial
DNA Primers
Genes, Bacterial
Gram-negative Bacterial Infections
Humans
Infant
Molecular Epidemiology
Molecular Sequence Data
Netherlands
Pertussis
Pertussis Toxin
Polymorphism, Genetic
Promoter Regions, Genetic
Research
Respiratory Tract Infections
Resurgence
Sequence Homology, Nucleic Acid
The Netherlands
Vaccination
Virulence
Virulence Factors, Bordetella
Whooping Cough
Young Adult
Whooping Cough

Source:
Emerg Infect Dis. 15(8):1206-1213.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:8fccf463d3ea40cc40aeb3522befe6a01cf3fd381f2ec561e7f8b65016ff5da4
File Type:

Supporting Files

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  	08-1511_appF-s2.gif	gif
  	08-1511_finalR.nxml	txt

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