Bordetella pertussis Strains with Increased Toxin Production Associated with Pertussis Resurgence
Published Date:Aug 2009
Source:Emerg Infect Dis. 15(8):1206-1213.
Bacterial Outer Membrane Proteins
Communicable Diseases, Emerging
Gram-negative Bacterial Infections
Molecular Sequence Data
Promoter Regions, Genetic
Respiratory Tract Infections
Sequence Homology, Nucleic Acid
Virulence Factors, Bordetella
Description:Before childhood vaccination was introduced in the 1940s, pertussis was a major cause of infant death worldwide. Widespread vaccination of children succeeded in reducing illness and death. In the 1990s, a resurgence of pertussis was observed in a number of countries with highly vaccinated populations, and pertussis has become the most prevalent vaccine-preventable disease in industrialized countries. We present evidence that in the Netherlands the dramatic increase in pertussis is temporally associated with the emergence of Bordetella pertussis strains carrying a novel allele for the pertussis toxin promoter, which confers increased pertussis toxin (Ptx) production. Epidemiologic data suggest that these strains are more virulent in humans. We discuss changes in the ecology of B. pertussis that may have driven this adaptation. Our results underline the importance of Ptx in transmission, suggest that vaccination may select for increased virulence, and indicate ways to control pertussis more effectively.
image/gif image/jpeg image/gif image/jpeg image/gif image/jpeg image/gif text/plain application/vnd.ms-excel text/plain
You May Also Like: