Bordetella pertussis Strains with Increased Toxin Production Associated with Pertussis Resurgence

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Mooi, Frits R. ; van Loo, Inge H.M. ; van Gent, Marjolein ; He, Qiushui ; Bart, Marieke J. ; Heuvelman, Kees J. ; de Greeff, Sabine C. ; Diavatopoulos, Dimitri ; Teunis, Peter ; Nagelkerke, Nico ; Mertsola, Jussi ; Mooi, Frits R. ; van Loo, Inge H.M. ; van Gent, Marjolein ; He, Qiushui ; Bart, Marieke J. ; Heuvelman, Kees J. ; de Greeff, Sabine C. ; Diavatopoulos, Dimitri ; Teunis, Peter ; Nagelkerke, Nico ; Mertsola, Jussi
• Description:
  Before childhood vaccination was introduced in the 1940s, pertussis was a major cause of infant death worldwide. Widespread vaccination of children succeeded in reducing illness and death. In the 1990s, a resurgence of pertussis was observed in a number of countries with highly vaccinated populations, and pertussis has become the most prevalent vaccine-preventable disease in industrialized countries. We present evidence that in the Netherlands the dramatic increase in pertussis is temporally associated with the emergence of Bordetella pertussis strains carrying a novel allele for the pertussis toxin promoter, which confers increased pertussis toxin (Ptx) production. Epidemiologic data suggest that these strains are more virulent in humans. We discuss changes in the ecology of B. pertussis that may have driven this adaptation. Our results underline the importance of Ptx in transmission, suggest that vaccination may select for increased virulence, and indicate ways to control pertussis more effectively.
• Subjects:
  Adolescent Alleles Bacteria Bacterial Outer Membrane Proteins Base Sequence Bordetella Pertussis Child Child, Preschool Communicable Diseases, Emerging DNA, Bacterial DNA Primers Genes, Bacterial Gram-negative Bacterial Infections Humans Infant Molecular Epidemiology Molecular Sequence Data Netherlands Pertussis Pertussis Toxin Polymorphism, Genetic Promoter Regions, Genetic Research Respiratory Tract Infections Resurgence Sequence Homology, Nucleic Acid The Netherlands Vaccination Virulence Virulence Factors, Bordetella Whooping Cough Young Adult

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• Source:
  Emerg Infect Dis. 15(8):1206-1213. ; Emerg Infect Dis. 15(8):1206-1213.
• Document Type:
  Journal Article
• Volume:
  15
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8fccf463d3ea40cc40aeb3522befe6a01cf3fd381f2ec561e7f8b65016ff5da4
• Download URL:
  https://stacks.cdc.gov/view/cdc/17478/cdc_17478_DS1.pdf
• File Type:
  [PDF - 688.38 KB ]