Oseltamivir-Resistant Influenza Virus A (H1N1), Europe, 2007–08 Season

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Meijer, Adam ; Lackenby, Angie ; Hungnes, Olav ; Lina, Bruno ; van der Werf, Sylvie ; Schweiger, Brunhilde ; Opp, Matthias ; Paget, John ; van de Kassteele, Jan ; Hay, Alan ; Zambon, Maria
• Corporate Authors:
  on behalf of the European Influenza Surveillance Scheme
• Description:
  In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward. Oseltamivir-resistant influenza viruses A (H1N1) (ORVs) with H275Y mutation in the neuraminidase emerged independently of drug use. By country, the proportion of ORVs ranged from 0% to 68%, with the highest proportion in Norway. The average weighted prevalence of ORVs across Europe increased gradually over time, from near 0 in week 40 of 2007 to 56% in week 19 of 2008 (mean 20%). Neuraminidase genes of ORVs possessing the H275Y substitution formed a homogeneous subgroup closely related to, but distinguishable from, those of oseltamivir-sensitive influenza viruses A (H1N1). Minor variants of ORVs emerged independently, indicating multiclonal ORVs. Overall, the clinical effect of ORVs in Europe, measured by influenza-like illness or acute respiratory infection, was unremarkable and consistent with normal seasonal activity.
• Subjects:
  Antiviral Agents Communicable Diseases, Emerging Drug Resistance, Viral Enzyme Inhibitors Genes, Viral Hemagglutinins, Viral Humans Influenza, Human Influenza A Virus, H1N1 Subtype Mutation Neuraminidase Oseltamivir Phylogeny Population Surveillance Seasons

  More +
• Source:
  Emerg Infect Dis. 15(4):552-560.
• Document Type:
  Journal Article
• Place as Subject:
  Europe
• Volume:
  15
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ac423a2cd70f0a1d2556513f568e94997133bb685c0e1edc6805ac934cfb9fa4
• Download URL:
  https://stacks.cdc.gov/view/cdc/17449/cdc_17449_DS1.pdf
• File Type:
  [PDF - 395.61 KB ]