Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Maragakis, Lisa L. ; Chaiwarith, Romanee ; Srinivasan, Arjun ; Torriani, Francesca J. ; Avdic, Edina ; Lee, Andrew ; Ross, Tracy R. ; Carroll, Karen C. ; Perl, Trish M.
• Description:
  Nationally distributed medications from compounding pharmacies, which typically adhere to less stringent quality-control standards than pharmaceutical manufacturers, can lead to multistate outbreaks. We investigated a cluster of 6 patients in a Maryland hospital who had Sphingomonas paucimobilis bloodstream infections in November 2007. Of the 6 case-patients, 5 (83%) had received intravenous fentanyl within 48 hours before bacteremia developed. Cultures of unopened samples of fentanyl grew S. paucimobilis; the pulsed-field gel electrophoresis pattern was indistinguishable from that of the isolates of 5 case-patients. The contaminated fentanyl lot had been prepared at a compounding pharmacy and distributed to 4 states. Subsequently, in California, S. paucimobilis bacteremia was diagnosed for 2 patients who had received intravenous fentanyl from the same compounding pharmacy. These pharmacies should adopt more stringent quality-control measures, including prerelease product testing, when compounding and distributing large quantities of sterile preparations.
• Subjects:
  Adult Aged Analgesics, Opioid Bacteremia Blood Culture Media Drug Contamination Electrophoresis, Gel, Pulsed-Field Female Fentanyl Gram-Negative Bacterial Infections Hospitals, University Humans Infusions, Intravenous Male Middle Aged Research

  More +
• Source:
  Emerg Infect Dis. 15(1):12-18.
• Document Type:
  Journal Article
• Funding:
  1 K01 CI000300/CI/NCPDCID CDC HHS/United States ; 1 R01 CI000530/CI/NCPDCID CDC HHS/United States
• Place as Subject:
  Maryland
• Location:
  North America
• Volume:
  15
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3ee6e484516d83e7f702c0be40386f5c4ff787ad8a2824f1ef81318da753eaaf
• Download URL:
  https://stacks.cdc.gov/view/cdc/17417/cdc_17417_DS1.pdf
• File Type:
  [PDF - 331.63 KB ]