Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Hauge, Siri H. ; Dudman, Susanne ; Borgen, Katrine ; Lackenby, Angie ; Hungnes, Olav
Hauge, Siri H. ; Dudman, Susanne ; Borgen, Katrine ; Lackenby, Angie ; Hungnes, Olav Less -
Description:
In Norway in January 2008, unprecedented levels of oseltamivir resistance were found in 12 of 16 influenza viruses A (H1N1) tested. To investigate the epidemiologic and clinical characteristics of these viruses, we used sequence analysis to test all available subtype H1N1 viruses from the 2007-08 season for resistance. Questionnaires from physicians provided information on predisposing diseases, oseltamivir use, symptoms, and complications. Clinical data were obtained for 265 patients. In total, 183 (67.3%) of 272 viruses were oseltamivir resistant. Resistance was not associated with prior use of antiviral drugs. Symptoms and hospitalization rates did not differ for patients infected with a resistant or a susceptible virus. Oseltamivir-resistant influenza viruses A (H1N1) did not show diminished capability to spread in the absence of selective pressure. The ability of these viruses to sustain their fitness and spread among persons should be considered when shaping future strategies for treating and preventing seasonal and pandemic influenza.
Subject:
[+]
Adolescent
Adult
Aged
Antiviral Agents
Child
Child, Preschool
Drug Resistance, Viral
Humans
Infant
Influenza, Human
Influenza A Virus, H1N1 Subtype
Microbial Sensitivity Tests
Middle Aged
Norway
Oseltamivir
Population Surveillance
Research
Seasons
Young Adult

Source:
Emerg Infect Dis. 15(2):155-162.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:be00ee6e9f62230c8d1ef9a712027c5401bae3b5e7dafd573e21283ab1fc4fb0
File Type:

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