Prospective Surveillance of Invasive Group A Streptococcal Disease, Fiji, 2005–2007

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Steer, Andrew C. ; Jenney, Adam ; Kado, Joseph ; Good, Michael F. ; Batzloff, Michael ; Waqatakirewa, Lepani ; Mullholland, E. Kim ; Carapetis, Jonathan R.
• Description:
  We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type. Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention.
• Subjects:
  Adolescent Adult Aged Anti-Bacterial Agents Bacterial Typing Techniques Child Child, Preschool Developing Countries Female Fiji Humans Incidence Infant Male Middle Aged Molecular Epidemiology Population Surveillance Prospective Studies Research Streptococcal Infections Streptococcal M Protein Streptococcus Pyogenes Young Adult

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• Source:
  Emerg Infect Dis. 15(2):216-222.
• Document Type:
  Journal Article
• Volume:
  15
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3038faaa051aa6e5d056ddf4fec98638dd15913b1a5b1c35f90021d8c9ea10d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/17305/cdc_17305_DS1.pdf
• File Type:
  [PDF - 180.79 KB ]