Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Gregori, Luisa ; Kovacs, Gabor G. ; Alexeeva, Irina ; Budka, Herbert ; Rohwer, Robert G.
Gregori, Luisa ; Kovacs, Gabor G. ; Alexeeva, Irina ; Budka, Herbert ; Rohwer, Robert G. Less -
Description:
The route of transmission of most naturally acquired transmissible spongiform encephalopathy (TSE) infections remains speculative. To investigate urine as a potential source of TSE exposure, we used a sensitive method for detection and quantitation of TSE infectivity. Pooled urine collected from 22 hamsters showing clinical signs of 263K scrapie contained 3.8 +/- 0.9 infectious doses/mL of infectivity. Titration of homogenates of kidneys and urinary bladders from the same animals gave concentrations 20,000-fold greater. Histologic and immunohistochemical examination of these same tissues showed no indications of inflammatory or other pathologic changes except for occasional deposits of disease-associated prion protein in kidneys. Although the source of TSE infectivity in urine remains unresolved, these results establish that TSE infectivity is excreted in urine and may thereby play a role in the horizontal transmission of natural TSEs. The results also indicate potential risk for TSE transmission from human urine-derived hormones and other medicines.
Subject:
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Animals Bladder Cricetinae Endogenous Infectivity Enzyme-Linked Immunosorbent Assay Hamster Kidney Limiting Dilution Titration Mesocricetus Pathology Prion Prion Diseases PrPSc Proteins Research Scrapie TSE Urinary Bladder Urine Research
Source:
Emerg Infect Dis. 14(9):1406-1412
Pubmed ID:
18760007
Pubmed Central ID:
PMC2603099
Document Type:
Journal Article
Funding:
N01-NS-0-2327/NS/NINDS NIH HHS/United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:e6e1cbdee6cda12b21326ee2d5895881939448565d1468d9129b87828b8c85db
Download URL:
https://stacks.cdc.gov/view/cdc/17239/cdc_17239_DS1.pdf
File Type:

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