Endemic and Epidemic Lineages of Escherichia coli that Cause Urinary Tract Infections

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Manges, Amee R. ; Tabor, Helen ; Tellis, Patricia ; Vincent, Caroline ; Tellier, Pierre-Paul
• Description:
  Women with urinary tract infections (UTIs) in California, USA (1999-2001), were infected with closely related or indistinguishable strains of Escherichia coli (clonal groups), which suggests point source dissemination. We compared strains of UTI-causing E. coli in California with strains causing such infections in Montréal, Québec, Canada. Urine specimens from women with community-acquired UTIs in Montréal (2006) were cultured for E. coli. Isolates that caused 256 consecutive episodes of UTI were characterized by antimicrobial drug susceptibility profile, enterobacterial repetitive intergenic consensus 2 PCR, serotyping, XbaI and NotI pulsed-field gel electrophoresis, multilocus sequence typing, and phylogenetic typing. We confirmed the presence of drug-resistant, genetically related, and temporally clustered E. coli clonal groups that caused community-acquired UTIs in unrelated women in 2 locations and 2 different times. Two clonal groups were identified in both locations. Epidemic transmission followed by endemic transmission of UTI-causing clonal groups may explain these clusters of UTI cases.
• Subjects:
  Adolescent Adult Antimicrobial Drug Resistance Bacterial Typing Techniques California Cluster Analysis Community-Acquired Infections Cross-Sectional Studies Disease Outbreaks DNA Fingerprinting Drug Resistance, Multiple, Bacterial Escherichia Coli Escherichia Coli Infections Extraintestinal Infections Female Humans Middle Aged Molecular Epidemiology Phylogeny Quebec Research Serotyping Urinary Tract Infections

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• Source:
  Emerg Infect Dis. 14(10):1575-1583
• Pubmed ID:
  18826822
• Pubmed Central ID:
  PMC2609861
• Document Type:
  Journal Article
• Volume:
  14
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5e2bf702130bb36712b9371295a2d56928bb92b152a61631f0f099da171bf1d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/17199/cdc_17199_DS1.pdf
• File Type:
  [PDF - 243.92 KB ]