Hantavirus Outbreak, Germany, 2007

Details

• Journal Article:
  Emerging Infectious Diseases
• Personal Author:
  Hofmann, Jörg ; Meisel, Helga ; Klempa, Boris ; Vesenbeckh, Silvan M. ; Beck, Robert ; Michel, Detlef ; Schmidt-Chanasit, Jonas ; Ulrich, Rainer G. ; Grund, Sebastian ; Enders, Gisela ; Kruger, Detlev H.
• Description:
  Hantavirus disease (for review see [1]) has been report- able in Germany since 2001, according to the Federal Infection Protection Act. In this country, Puumala virus (PUUV) causes most clinical hantavirus cases, although Dobrava-Belgrade virus and Tula virus also circulate (1). From 2001 through 2006, an aver- age of ≈220 cases were reported per year (incidence 0.267/100,000) with a maximum of 448 cases in 2005. In contrast, 1,687 cases were reported in 2007 (2). Whereas in 2005 the highest incidence of infection was in metropolitan areas (3), the current outbreak is focused in the rural areas in southern and western Germany. Clinical case- patients exhibit key characteristics of hantavirus disease (nephropathia epidemica): acute high fever; pain in the back, head, and/or abdomen; proteinuria; rise of serum creatinine; thrombocytopenia; and renal failure (1). The outbreak provided considerable numbers of clinical samples from the viremic phase and thus has enabled a molecular epidemiologic analysis of the circulating virus.
• Subjects:
  Animals Arvicolinae Disease Outbreaks Hantavirus Infections Hemorrhagic Fever With Renal Syndrome Humans Orthohantavirus Phylogeny Sequence Analysis, DNA Zoonoses
• Series:
  Emerging Infectious Diseases
• DOI:
  https://doi.org/10.3201/eid1405.071533
• ISSN:
  1080-6059 (digital) ; 1080-6040 (print)
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Pubmed ID:
  18439382
• Pubmed Central ID:
  PMC2600236
• Document Type:
  Text
• Genre:
  Letter
• Place as Subject:
  Germany
• Rights:
  Public Domain
• Topic:
  Diseases & Conditions
• Location:
  Europe
• Volume:
  14
• Issue:
  5
• Citation:
  Emerg Infect Dis. 14(5):850-852.
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:49be1291283e8b77fe27fb191618b639fdb8202344c63f04ba2970c7be35248b680d3dadd92b8f76514521e8b8a94b66376afaa889c64ba91acabe48b20ab304
• Download URL:
  https://stacks.cdc.gov/view/cdc/17131/cdc_17131_DS1.pdf
• File Type:
  [PDF - 133.67 KB ]