Family History of Arthritis, Osteoporosis, and Carpal Tunnel Syndrome and Risk of These Conditions Among US Adults

Details

• Alternative Title:
  Arthritis Care Res (Hoboken)
• Personal Author:
  Rasooly, Danielle ; Moonesinghe, Ramal ; Fallon, Elizabeth ; Barbour, Kamil E. ; Khoury, Muin J.
• Description:
  Objective.
  
  The aim was to estimate odds ratios (ORs) of associations between family history of arthritis, osteoporosis, and carpal tunnel syndrome and prevalence in a real-world population, uncovering family histories of related conditions that may increase risk because of shared heritability, condition pathophysiology, or social/environmental factors.
  
  Methods.
  
  Using data from 156,307 participants in the All of Us (AoU) Research Program, we examined associations between self-reported first-degree family history of five common types of arthritis (fibromyalgia, gout, osteoarthritis [OA], rheumatoid arthritis, and systemic lupus erythematosus [SLE]), osteoporosis, and carpal tunnel syndrome and prevalence. We evaluate associations across seven conditions and performed stratified analyses by race and ethnicity, sex, socioeconomic differences, body mass index, and type of affected relative.
  
  Results.
  
  More than 38% of AoU participants reported a family history of any arthritis, osteoporosis, or carpal tunnel syndrome. Adults with a family history of any arthritis, osteoporosis, and carpal tunnel syndrome exhibited 3.68 to 7.59 (4.90, on average) odds of having the same condition and 0.70 to 2.10 (1.24, on average) odds of having a different condition. The strongest associations observed were between family history of OA and prevalence of OA (OR 7.59; 95% confidence interval [95% CI] 7.32–7.88) and family history of SLE and prevalence of SLE (OR 6.34; 95% CI 5.17–7.74). We additionally uncover race and ethnicity and sex disparities in family history associations.
  
  Conclusion.
  
  Family history of several related conditions was associated with increased risk for arthritis, osteoporosis, and carpal tunnel syndrome, underscoring the importance of family history of related conditions for primary prevention.
  
  
• Subjects:
  Adult Aged Arthritis Carpal Tunnel Syndrome Female Genetic Predisposition To Disease Humans Male Middle Aged Odds Ratio Osteoporosis Prevalence Risk Assessment Risk Factors United States

  More +
• Source:
  Arthritis Care Res (Hoboken). 76(12):1733-1743
• Pubmed ID:
  39155684
• Pubmed Central ID:
  PMC11606734
• Document Type:
  Journal Article
• Funding:
  1 OT2 OD026549/GF/NIH HHSUnited States/ ; 1 OT2 OD026555/GF/NIH HHSUnited States/ ; 1 OT2 OD026554/GF/NIH HHSUnited States/ ; 5 U2C OD023196/data and research center/ ; 1 OT2 OD026556/GF/NIH HHSUnited States/ ; U24 OD023176/CD/ODCDC CDC HHSUnited States/ ; 1 OT2 OD025276/community partners/ ; 3 OT2 OD025315/community partners/ ; 3 OT2 OD023205/communications and engagement/ ; AOD 16037/IAA/ ; 1 OT2 OD026553/GF/NIH HHSUnited States/ ; 1 OT2 OD025277/community partners/ ; HHSN 263201600085U/federally qualified health centers/ ; 1 U24 OD023121/biobank/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; 1 OT2 OD026557/GF/NIH HHSUnited States/ ; 3 OT2 OD023206/communications and engagement/ ; 1 U24 OD023163/participant technology systems center/ ; 1 OT2 OD026550/GF/NIH HHSUnited States/ ; 1 OT2 OD026551/GF/NIH HHSUnited States/ ; 1 OT2 OD025337/community partners/ ; 1 OT2 OD 026552/GF/NIH HHSUnited States/ ; 1 OT2 OD026548/GF/NIH HHSUnited States/
• Volume:
  76
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:92e77e15d3f971ec5e5e7f6ed92ac607fadf344dc766054234993b8281865f1963880a30b4a2ba9c8f71595c8c04dc51368fb0536969efe798b074c75861d0a6
• Download URL:
  https://stacks.cdc.gov/view/cdc/170799/cdc_170799_DS1.pdf
• File Type:
  [PDF - 593.04 KB ]