Household Transmission Dynamics of Seasonal Human Coronaviruses

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Quandelacy, Talia M. ; Hitchings, Matt D. T. ; Lessler, Justin ; Read, Jonathan M. ; Vukotich, Charles ; Azman, Andrew S. ; Salje, Henrik ; Zimmer, Shanta ; Gao, Hongjiang ; Zheteyeva, Yenlik ; Uzicanin, Amra ; Cummings, Derek A. T.
  More +
• Description:
  Background. ; Household transmission studies inform how viruses spread among close contacts, but few characterize household transmission of endemic coronaviruses. ; Methods. ; We used data collected from 223 households with school-age children participating in weekly disease surveillance over 2 respiratory virus seasons (December 2015 to May 2017), to describe clinical characteristics of endemic human coronaviruses (HCoV-229E, HcoV-HKU1, HcoV-NL63, HcoV-OC43) infections, and community and household transmission probabilities using a chain-binomial model correcting for missing data from untested households. ; Results. ; Among 947 participants in 223 households, we observed 121 infections during the study, most commonly subtype HCoV-OC43. Higher proportions of infected children (<19 years) displayed influenza-like illness symptoms than infected adults (relative risk, 3.0; 95% credible interval CrI, 1.5–6.9). The estimated weekly household transmission probability was 9% (95% CrI, 6–13) and weekly community acquisition probability was 7% (95% CrI, 5–10). We found no evidence for differences in community or household transmission probabilities by age or symptom status. Simulations suggest that our study was underpowered to detect such differences. ; Conclusions. ; Our study highlights the need for large household studies to inform household transmission, the challenges in estimating household transmission probabilities from asymptomatic individuals, and implications for controlling endemic CoVs.
• Subjects:
  • Child
  • Adult
  • Humans
  • Seasons
  • Respiratory Tract Infections
  • Coronavirus Infections
  • Coronavirus 229E, Human
  • Viruses
  • Coronavirus OC43, Human
  • Coronavirus NL63, Human
• Keywords:
  • children
  • coronaviruses
  • household
  • transmission
• Source:
  J Infect Dis. 227(9):1104-1112
• Pubmed ID:
  36350773
• Pubmed Central ID:
  PMC11584005
• Document Type:
  Journal Article
• Funding:
  U01 CK000337/CK/NCEZID CDC HHSUnited States/ ; U01 CK000337-01/CC/CDC HHSUnited States/ ; MR/V038613/1/MRC_/Medical Research CouncilUnited Kingdom/
• Volume:
  227
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/170651/cdc_170651_DS1.pdf
• File Type:
  [PDF - 996.93 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:1a402e2dbbdf0cb384d9853b2024ca48bf2400df3110e30dc664fc688a55f98ceb988396d9f68eb439d9cb1462f55999e8f588a2f8675c7f428c21a0667c45c5