Threat of Dengue to Blood Safety in Dengue-Endemic Countries

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Wilder-Smith, Annelies ; Chen, Lin H. ; Massad, Eduardo ; Wilson, Mary E.
• Description:
  Dengue, the most common arbovirus infection globally, is transmitted by mosquito vectors. Healthcare-related transmission, including transmission by blood products, has been documented, although the frequency of these occurrences is unknown. Dengue is endemic to Singapore, a city-state in Asia. Using mathematical modeling, we estimated the risk for dengue-infected blood transfusions in Singapore in 2005 to be 1.625-6/10,000 blood transfusions, assuming a ratio of asymptomatic to symptomatic infections of 2:1 to 10:1. However, the level of viremia required to cause clinical dengue cases is person-dependent and unknown. Further studies are needed to establish the magnitude of the threat that dengue poses to blood safety in countries where it is endemic. It will then be possible after this information is obtained to assess whether screening is feasible and to identify approaches that are most cost-effective on the basis of characteristics of local populations and seasonality of dengue.
• Subjects:
  Adolescent Adult Blood Blood Safety Blood Transfusion Blood Transfusions Dengue Dengue Virus Endemic Diseases Healthcare-associated Dengue Humans Mass Screening Models, Biological Non-vector Transmission Nosocomial Transmission Parenteral Transmission Perspective Risk Assessment Singapore Young Adult

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• Source:
  Emerg Infect Dis. 15(1):8-11.
• Document Type:
  Journal Article
• Volume:
  15
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a6f22fd8dcd85041cb1ae58080086360b4f3a787f40c6aacdd5f0e3710fbf352
• Download URL:
  https://stacks.cdc.gov/view/cdc/17005/cdc_17005_DS1.pdf
• File Type:
  [PDF - 45.76 KB ]