Clonal Population of Flucytosine-Resistant Candida tropicalis from Blood Cultures, Paris, France
Published Date:Apr 2008
Source:Emerg Infect Dis. 14(4):557-565.
Corporate Authors:YEASTS group
Antifungal Drug Resistance
Drug Resistance, Fungal
Multilocus Sequence Typing
Polymorphic Microsatellite Markers
Description:Candida tropicalis is a diploid ascomycetes yeast responsible for 4%-24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone.
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