Serological Evidence of Mpox Virus Infection During Peak Mpox Transmission in New York City, July to August 2022

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Pathela, Preeti ; Townsend, Michael B. ; Kopping, Erik J. ; Tang, Jennifer ; Navarra, Terese ; Priyamvada, Lalita ; Carson, William C. ; Panayampalli, S Satheshkumar ; Fowler, Randal C. ; Kyaw, Nang ; Hughes, Scott ; Jamison, Kelly
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• Description:
  Background. ; The extent to which infections may have been undetected in an epicenter of the 2022 mpox outbreak is unknown. ; Methods. ; A serosurvey (July and August 2022) assessed the seroprevalence and correlates of mpox infection among a diverse sample of asymptomatic patients with no prior mpox diagnoses and no known histories of smallpox or mpox vaccination. We present seropositivity stratified by participant characteristics collected via survey. ; Results. ; Two-thirds of 419 participants were cismen (281 of 419), of whom 59.1% (166 of 281) reported sex with men (MSM). The sample also included 109 ciswomen and 28 transgender/gender nonconforming/nonbinary individuals. Overall seroprevalence was 6.4% (95% confidence interval CI, 4.1%–8.8%); 3.7% among ciswomen (95% CI, 1.0%–9.1%), 7.0% among cismen with only ciswomen partners (95% CI, 2.0%–11.9%), and 7.8% among MSM (95% CI, 3.7%–11.9%). There was little variation in seroprevalence by race/ethnicity, age group, HIV status, or number of recent sex partners. No participants who reported close contact with mpox cases were seropositive. Among participants without recent mpox-like symptoms, 6.3% were seropositive (95% CI, 3.6%–9.0%). ; Conclusions. ; Approximately 1 in 15 vaccine-naive people in our study had antibodies to mpox during the height of the NYC outbreak, indicating the presence of asymptomatic infections that could contribute to ongoing transmission.
• Subjects:
  • Humans
  • Male
  • Female
  • Seroepidemiologic Studies
  • Adult
  • New York City
  • Young Adult
  • Middle Aged
  • Adolescent
  • Mpox (monkeypox)
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• Keywords:
  • mpox
  • asymptomatic infections
  • subclinical infections
  • serosurvey
  • outbreak
• Source:
  J Infect Dis. 230(5):1102-1109
• Pubmed ID:
  38736232
• Pubmed Central ID:
  PMC11557731
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  230
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/169975/cdc_169975_DS1.pdf
• File Type:
  [PDF - 121.27 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:da0f7bf4e4ad0bd053740b727051aeaa0d52851dd70945b374817cc38edfa560aa41d606141d128bae367c9c305f644523446929c9631d0bc8737db6d5629f36