A Prospective Study of Etiology of Childhood Acute Bacterial Meningitis, Europe

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• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ceyhan, Mehmet ; Yildirim, Inci ; Balmer, Paul ; Borrow, Ray ; Dikici, Bunyamin ; Turgut, Mehmet ; Kurt, Nese ; Aydogan, Aysel ; Ecevit, Cigdem ; Anlar, Yasar ; Gulumser, Ozlem ; Tanir, Gonul ; Salman, Nuran ; Gurler, Nezahat ; Hatipoglu, Nevin ; Hacimustafaoglu, Mustafa ; Celebi, Solmaz ; Coskun, Yavuz ; Alhan, Emre ; Celik, Umit ; Camcioglu, Yildiz ; Secmeer, Gulten ; Gur, Deniz ; Gray, Steve
• Description:
  Determination of the etiology of bacterial meningitis and estimating cost of disease are important in guiding vaccination policies. To determine the incidence and etiology of meningitis in Europe, cerebrospinal fluid (CSF) samples were obtained prospectively from children (1 month-17 years of age) with a clinical diagnosis of acute bacterial meningitis. Multiplex PCR was used to detect DNA evidence of Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), and Neisseria meningitidis. In total, 408 CSF samples were collected, and bacterial etiology was determined in 243 cases; N. meningitidis was detected in 56.5%, S. pneumoniae in 22.5%, and Hib in 20.5% of the PCR-positive samples. Among N. meningitidis-positive CSF samples, 42.7%, 31.1%, 2.2%, and 0.7% belonged to serogroups W-135, B, Y, and A, respectively. This study highlights the emergence of serogroup W-135 disease in Europe and concludes that vaccines to prevent meningococcal disease in this region must provide reliable protection against this serogroup.
• Subjects:
  Adolescent Bacterial Meningitis Child Child, Preschool Epidemiology Europe Female Haemophilus Influenzae Type B Humans Incidence Infant Male Meningitis, Bacterial Meningococcal Vaccine Molecular Epidemiology Neisseria Meningitidis Population Surveillance Prospective Studies Research Serogroup W-135 Streptococcus Pneumoniae

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• Source:
  Emerg Infect Dis. 14(7):1089-1096.
• Document Type:
  Journal Article
• Volume:
  14
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:41179a65a36c7665394bcca237a865a911d604117c2f2547fb810510d5ffa526
• Download URL:
  https://stacks.cdc.gov/view/cdc/16958/cdc_16958_DS1.pdf
• File Type:
  [PDF - 296.25 KB ]