Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lamagni, Theresa L. ; Neal, Shona ; Keshishian, Catherine ; Alhaddad, Neelam ; George, Robert ; ... More +
Lamagni, Theresa L. ; Neal, Shona ; Keshishian, Catherine ; Alhaddad, Neelam ; George, Robert ; Duckworth, Georgia ; Vuopio-Varkila, Jaana ; Efstratiou, Androulla ; Less -
Description:
As part of a Europe-wide initiative to explore current epidemiologic patterns of severe disease caused by Streptococcus pyogenes, the United Kingdom undertook enhanced population-based surveillance during 2003-2004. A total of 3,775 confirmed cases of severe S. pyogenes infection were identified over 2 years, 3.33/100,000 population, substantially more than previously estimated. Skin/soft tissue infections were the most common manifestation (42%), followed by respiratory tract infections (17%). Injection drug use was identified as a risk factor for 20% of case-patients. One in 5 infected case-patients died within 7 days of diagnosis; the highest mortality rate was for cases of necrotizing fasciitis (34%). Nonsteroidal antiinflammatory drugs, alcoholism, young age, and infection with emm/M3 types were independently associated with increased risk for streptococcal toxic shock syndrome. Understanding the pattern of these diseases and predictors of poor patient outcome will help with identification and assessment of the potential effect of targeted interventions.
Subject:
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Adolescent
Adult
Aged
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Population Surveillance
Respiratory Tract Infections
Risk Factors
Seasons
Severity Of Illness Index
Skin Diseases, Bacterial
Soft Tissue Infections
Streptococcal Infections

Source:
Emerg Infect Dis. 14(2):202-209.
Document Type:
Journal Article ;
Place as Subject:
United Kingdom ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:39c5065fbd5c0a3715270014b9d34242f7d674a8f8baa03d475d4a3dcd430503
File Type:

Supporting Files

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