Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lierz, Michael ; Hafez, Hafez M. ; Klopfleisch, Robert ; Lüschow, Dörte ; Prusas, Christine ; ... More +
Lierz, Michael ; Hafez, Hafez M. ; Klopfleisch, Robert ; Lüschow, Dörte ; Prusas, Christine ; Teifke, Jens P. ; Rudolf, Miriam ; Grund, Christian ; Kalthoff, Donata ; Mettenleiter, Thomas ; Beer, Martin ; Harder, Timm ; Less -
Description:
Because fatal infections with highly pathogenic avian influenza A (HPAI) virus subtype H5N1 have been reported in birds of prey, we sought to determine detailed information about the birds' susceptibility and protection after vaccination. Ten falcons vaccinated with an inactivated influenza virus (H5N2) vaccine seroconverted. We then challenged 5 vaccinated and 5 nonvaccinated falcons with HPAI (H5N1). All vaccinated birds survived; all unvaccinated birds died within 5 days. For the nonvaccinated birds, histopathologic examination showed tissue degeneration and necrosis, immunohistochemical techniques showed influenza virus antigen in affected tissues, and these birds shed high levels of infectious virus from the oropharynx and cloaca. Vaccinated birds showed no influenza virus antigen in tissues and shed virus at lower titers from the oropharynx only. Vaccination could protect these valuable birds and, through reduced virus shedding, reduce risk for transmission to other avian species and humans.
Subject:
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Animals
Antibody Titer
Bird Diseases
Challenge
Falcon Hybrids
Falconiformes
Female
Fowl Plague
H5N1
Highly Pathogenic Avian Influenza
Histopathology
Human Risk
Immunohistochemistry
Influenza A Virus, H5N1 Subtype
Influenza A Virus, H5N2 Subtype
Influenza In Birds
Influenza Vaccines
Keywords: Birds Of Prey
Research
Treatment Outcome
Vaccines, Inactivated
Virus Shedding
Zoonosis
Virus Shedding

Source:
Emerg Infect Dis. 13(11):1667-1674. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:c51e11451da57da1d3b32b781df147da0ecc58aba0dc9ebbd36da73e2a9c3a8c
File Type:

Supporting Files

• 	license.txt	txt
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  	07-0705-F1.jpg	jpeg
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  	07-0705-F2.jpg	jpeg
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  	07-0705_finalR.nxml	txt

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