Protection and Virus Shedding of Falcons Vaccinated against Highly Pathogenic Avian Influenza A Virus (H5N1)

Lierz, Michael; Hafez, Hafez M.; Klopfleisch, Robert; Lüschow, Dörte; Prusas, Christine; Teifke, Jens P.; Rudolf, Miriam; Grund, Christian; Kalthoff, Donata; Mettenleiter, Thomas; Beer, Martin; Harder, Timm

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Protection and Virus Shedding of Falcons Vaccinated against Highly Pathogenic Avian Influenza A Virus (H5N1)

Published Date:

Nov 2007

Source:

Emerg Infect Dis. 13(11):1667-1674.

[PDF-431.34 KB]

Details:

Personal Authors:

Lierz, Michael ; Hafez, Hafez M. ; Klopfleisch, Robert ; Lüschow, Dörte ; Prusas, Christine ; ... More ▼

Keywords:

[+]

Description:

Because fatal infections with highly pathogenic avian influenza A (HPAI) virus subtype H5N1 have been reported in birds of prey, we sought to determine detailed information about the birds' susceptibility and protection after vaccination. Ten falcons vaccinated with an inactivated influenza virus (H5N2) vaccine seroconverted. We then challenged 5 vaccinated and 5 nonvaccinated falcons with HPAI (H5N1). All vaccinated birds survived; all unvaccinated birds died within 5 days. For the nonvaccinated birds, histopathologic examination showed tissue degeneration and necrosis, immunohistochemical techniques showed influenza virus antigen in affected tissues, and these birds shed high levels of infectious virus from the oropharynx and cloaca. Vaccinated birds showed no influenza virus antigen in tissues and shed virus at lower titers from the oropharynx only. Vaccination could protect these valuable birds and, through reduced virus shedding, reduce risk for transmission to other avian species and humans.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

	07-0705-F1.gif	image/gif
	07-0705-F1.jpg	image/jpeg
	07-0705-F2.gif	image/gif
	07-0705-F2.jpg	image/jpeg
	07-0705-F3.gif	image/gif
	07-0705-F3.jpg	image/jpeg
	07-0705_finalR.nxml	text/plain

No Related Documents.

You May Also Like:

Highly (H5N1) and Low (H7N2) Pathogenic Avian Influenza Virus Infection in Falcons Via Nasochoanal Route and Ingestion of Experimentally Infected Prey

Personal Author:

Bertran, Kateri; Busquets, Núria; Abad, Francesc Xavier; García de la Fuente, Jorge; Solanes, David; Cordón, Iván; Costa, Taiana; Dolz, Roser; Majó, Natàlia;

Published:

Mar 09 2012

Source:

PLoS One. 2012; 7(3).

Description:

An experimental infection with highly pathogenic avian influenza (HPAI) and low pathogenic avian influenza (LPAI) viruses was carried out on falcons in order to examine the effects of these viruses in terms of pathogenesis, viral distribution in tiss...

File Type:

[PDF - 463.85 KB]
H5N1 Outbreaks and Enzootic Influenza

Personal Author:

Webster, Robert G.; Peiris, Malik; Chen, Honglin; Guan, Yi;

Published:

Jan 2006

Source:

Emerg Infect Dis. 12(1):3-8.

Description:

Ongoing outbreaks of H5N1 avian influenza in migratory waterfowl, domestic poultry, and humans in Asia during the summer of 2005 present a continuing, protean pandemic threat. We review the zoonotic source of highly pathogenic H5N1 viruses and their ...

File Type:

[PDF - 205.83 KB]
Spread of Influenza Virus A (H5N1) Clade 2.3.2.1 to Bulgaria in Common Buzzards

Personal Author:

Marinova-Petkova, Atanaska; Georgiev, Georgi; Seiler, Patrick; Darnell, Daniel; Franks, John; Krauss, Scott; Webby, Richard J.; Webster, Robert G.;

Published:

Oct 2012

Source:

Emerg Infect Dis. 18(10):1596-1602.

Description:

On March 15, 2010, a highly pathogenic avian influenza virus was isolated from the carcass of a common buzzard (Buteo buteo) in Bulgaria. Phylogenetic analyses of the virus showed a close genetic relationship with influenza virus A (H5N1) clade 2.3.2...

File Type:

[PDF - 286.87 KB]
Neuraminidase-based recombinant virus-like particles protect against lethal avian influenza A(H5N1) virus infection in ferrets

Personal Author:

Smith, Gale E.; Sun, Xiangjie; Bai, Yaohui; Liu, Ye V.; Massare, Michael J.; Pearce, Melissa B.; Belser, Jessica A.; Maines, Taronna R.; Creager, Hannah M.; Glenn, Gregory M.; Flyer, David; Pushko, Peter; Levine, Min Z.; Tumpey, Terrence M.;

Published:

Jun 16 2017

Source:

Virology. 509:90-97.

Description:

Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections further emphasizes the need for vaccine strategies for control of pre-pandemic H5N1 and other avian inf...

File Type:

[PDF - 965.91 KB]
Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets

Personal Author:

Liu, Ye V.; Massare, Michael J.; Pearce, Melissa B.; Sun, Xiangjie; Belser, Jessica A.; Maines, Taronna R.; Creager, Hannah M.; Glenn, Gregory M.; Pushko, Peter; Smith, Gale E.; Tumpey, Terrence M.;

Published:

Mar 13 2015

Source:

Vaccine. 33(18):2152-2158.

Description:

In March 2013, diagnosis of the first reported case of human infection with a novel avian-origin influenza A(H7N9) virus occurred in eastern China. Most human cases have resulted in severe respiratory illness and, in some instances, death. Currently ...

File Type:

[PDF - 489.39 KB]