Protection and Virus Shedding of Falcons Vaccinated against Highly Pathogenic Avian Influenza A Virus (H5N1)

Lierz, Michael; Hafez, Hafez M.; Klopfleisch, Robert; Lüschow, Dörte; Prusas, Christine; Teifke, Jens P.; Rudolf, Miriam; Grund, Christian; Kalthoff, Donata; Mettenleiter, Thomas; Beer, Martin; Harder, Timm

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Protection and Virus Shedding of Falcons Vaccinated against Highly Pathogenic Avian Influenza A Virus (H5N1)

Supporting Files Public Domain

Nov 2007
By Lierz, Michael ; Hafez, Hafez M. ; Klopfleisch, Robert ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Lierz, Michael ; Hafez, Hafez M. ; Klopfleisch, Robert ; Lüschow, Dörte ; Prusas, Christine ; Teifke, Jens P. ; Rudolf, Miriam ; Grund, Christian ; Kalthoff, Donata ; Mettenleiter, Thomas ; Beer, Martin ; Harder, Timm
Description:

Because fatal infections with highly pathogenic avian influenza A (HPAI) virus subtype H5N1 have been reported in birds of prey, we sought to determine detailed information about the birds' susceptibility and protection after vaccination. Ten falcons vaccinated with an inactivated influenza virus (H5N2) vaccine seroconverted. We then challenged 5 vaccinated and 5 nonvaccinated falcons with HPAI (H5N1). All vaccinated birds survived; all unvaccinated birds died within 5 days. For the nonvaccinated birds, histopathologic examination showed tissue degeneration and necrosis, immunohistochemical techniques showed influenza virus antigen in affected tissues, and these birds shed high levels of infectious virus from the oropharynx and cloaca. Vaccinated birds showed no influenza virus antigen in tissues and shed virus at lower titers from the oropharynx only. Vaccination could protect these valuable birds and, through reduced virus shedding, reduce risk for transmission to other avian species and humans.
Subjects:

Animals Antibody Titer Bird Diseases Challenge Falcon Hybrids Falconiformes Female Fowl Plague H5N1 Highly Pathogenic Avian Influenza Histopathology Human Risk Immunohistochemistry Influenza A Virus, H5N1 Subtype Influenza A Virus, H5N2 Subtype Influenza In Birds Influenza Vaccines Keywords: Birds Of Prey Research Treatment Outcome Vaccines, Inactivated Virus Shedding Zoonosis
Source:

Emerg Infect Dis. 13(11):1667-1674.
Document Type:

Journal Article
Volume:

13
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:c51e11451da57da1d3b32b781df147da0ecc58aba0dc9ebbd36da73e2a9c3a8c
Download URL:

https://stacks.cdc.gov/view/cdc/16888/cdc_16888_DS1.pdf
File Type:

[PDF - 431.34 KB ]

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