Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Van Tu, Phan; Thao, Nguyen Thi Thanh; Perera, David; Truong, Khanh Huu; Tien, Nguyen Thi Kim; ... More +
Van Tu, Phan; Thao, Nguyen Thi Thanh; Perera, David; Truong, Khanh Huu; Tien, Nguyen Thi Kim; Thuong, Tang Chi; How, Ooi Mong; Cardosa, Mary Jane; McMinn, Peter Charles; Less -
Description:
During 2005, 764 children were brought to a large children's hospital in Ho Chi Minh City, Vietnam, with a diagnosis of hand, foot, and mouth disease. All enrolled children had specimens (vesicle fluid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identified HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was isolated throughout the year, with a period of higher prevalence in October-November. Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.
Subject:
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Adolescent
Animals
Capsid Proteins
Cell Line, Tumor
Cercopithecus Aethiops
Child
Enterovirus A, Human
Hand, Foot And Mouth Disease
Humans
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction
Vero Cells

Source:
Emerg Infect Dis. 13(11):1733-1741.;
Document Type:
Journal Article;
Place as Subject:
Vietnam;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:24327eb4a6708fb0fee2c0bd444423672721e2b1c66193db6aa94f7b74768af8
File Type:

Supporting Files

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