Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005

Van Tu, Phan; Thao, Nguyen Thi Thanh; Perera, David; Truong, Khanh Huu; Tien, Nguyen Thi Kim; Thuong, Tang Chi; How, Ooi Mong; Cardosa, Mary Jane; McMinn, Peter Charles

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Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005

Published Date:

Nov 2007

Source:

Emerg Infect Dis. 13(11):1733-1741.

[PDF-460.72 KB]

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Alternative Title:

Emerg Infect Dis

Personal Author:

Van Tu, Phan ; Thao, Nguyen Thi Thanh ; Perera, David ; Truong, Khanh Huu ; Tien, Nguyen Thi Kim ; ... More ▼

Description:

During 2005, 764 children were brought to a large children's hospital in Ho Chi Minh City, Vietnam, with a diagnosis of hand, foot, and mouth disease. All enrolled children had specimens (vesicle fluid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identified HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was isolated throughout the year, with a period of higher prevalence in October-November. Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.

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Journal Article

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Emerging Infectious Diseases

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Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005

Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005

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