High Rate of Mobilization for blaCTX-Ms
Published Date:Mar 2008
Source:Emerg Infect Dis. 14(3):423-428.
Drug Resistance, Multiple, Bacterial
Gene Transfer, Horizontal
Test For Selection
Description:We constructed a phylogenetic analysis of class A beta-lactamases and found that the blaCTX-Ms have been mobilized to plasmids approximately 10 times more frequently than other class A beta-lactamases. We also found that the blaCTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for blaCTX-Ms in the pre-antimicrobial drug era.
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