High Rate of Mobilization for blaCTX-Ms

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Barlow, Miriam ; Reik, Rebecca A. ; Jacobs, Stephen D. ; Medina, Mónica ; Meyer, Matthew P. ; McGowan, John E. ; Tenover, Fred C.
• Description:
  We constructed a phylogenetic analysis of class A beta-lactamases and found that the blaCTX-Ms have been mobilized to plasmids approximately 10 times more frequently than other class A beta-lactamases. We also found that the blaCTX-Ms are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for blaCTX-Ms in the pre-antimicrobial drug era.
• Subjects:
  Anti-Bacterial Agents Antimicrobial Resistance Bacteria Bayesian Inference Beta-lactamase Beta-Lactamases Class A CTX-M DNA, Bacterial Drug Resistance, Multiple, Bacterial Evolution Evolution, Molecular Genetic Variation Gene Transfer, Horizontal Mobilization Phylogenetic Analysis Phylogeny Plasmid Plasmids Protein Transport Research Test For Selection

  More +
• Source:
  Emerg Infect Dis. 14(3):423-428.
• Document Type:
  Journal Article
• Volume:
  14
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:75c10648305f53509fa06afebf3a7fcd9d08a33318596cfa76f4da9aee8db175
• Download URL:
  https://stacks.cdc.gov/view/cdc/16794/cdc_16794_DS1.pdf
• File Type:
  [PDF - 253.05 KB ]