Zinc Cream and Reliability of Tuberculosis Skin Testing
Published Date:Jul 2007
Source:Emerg Infect Dis. 13(7):1101-1104.
False Negative Reactions
Purified Protein Derivative
Reproducibility Of Results
Sensitivity And Specificity
Description:In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.
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