Zinc Cream and Reliability of Tuberculosis Skin Testing

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rao, V. Bhargavi ; Pelly, Tom F. ; Gilman, Robert H. ; Cabrera, Lilia ; Delgado, Jose ; Soto, Giselle ; Friedland, Jon S. ; Escombe, A. Roderick ; Black, Robert E. ; Evans, Carlton A.
• Description:
  In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.
• Subjects:
  Administration, Topical Adult Diagnosis Diagnosis, Differential Dispatch Double-Blind Method False Negative Reactions Female Humans Male Nutrition Nutritional Status Peru Purified Protein Derivative Reproducibility Of Results Risk Factors Sensitivity And Specificity Skin Social Class Socioeconomic Factors Trace Elements Tuberculin Tuberculin Test Tuberculosis Zinc

  More +
• Source:
  Emerg Infect Dis. 13(7):1101-1104.
• Document Type:
  Journal Article
• Volume:
  13
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:23c1395038a8c70dadfd73713996e0dd6b845070cc440205a4bd4e9d7c9b9b00
• Download URL:
  https://stacks.cdc.gov/view/cdc/16739/cdc_16739_DS1.pdf
• File Type:
  [PDF - 277.34 KB ]