Reduced Sensitivity of Influenza A (H5N1) to Oseltamivir

McKimm-Breschkin, Jennifer L.; Selleck, Paul W.; Usman, Tri Bhakti; Johnson, Michael A.

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Reduced Sensitivity of Influenza A (H5N1) to Oseltamivir

Supporting Files Public Domain

Sep 2007
By McKimm-Breschkin, Jennifer L. ; Selleck, Paul W. ; Usman, Tri Bhakti ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

McKimm-Breschkin, Jennifer L. ; Selleck, Paul W. ; Usman, Tri Bhakti ; Johnson, Michael A.
Description:

We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared with the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.
Subjects:

Antiviral Agents Antiviral Drug Resistance Avian Influenza Dispatch Drug Resistance, Viral H5N1 Influenza A Virus, H5N1 Subtype Neuraminidase Oseltamivir Sialic Acids Zanamivir
Source:

Emerg Infect Dis. 13(9):1354-1357.
Document Type:

Journal Article
Volume:

13
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d226098c6a333cbdfacb2f10bd3e6e82c87ff1956468eb411ec5aa08b9793831
Download URL:

https://stacks.cdc.gov/view/cdc/16722/cdc_16722_DS1.pdf
File Type:

[PDF - 263.57 KB ]

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