Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Harris, Anthony D. ; McGregor, Jessina C. ; Johnson, Judith A. ; Strauss, Sandra M. ; Moore, Anita C. ; ... More +
Harris, Anthony D. ; McGregor, Jessina C. ; Johnson, Judith A. ; Strauss, Sandra M. ; Moore, Anita C. ; Standiford, Harold C. ; Hebden, Joan N. ; Morris, J. Glenn Less -
Description:
Extended-spectrum beta-lactamase (ESBL)-producing bacteria are emerging pathogens. To analyze risk factors for colonization with ESBL-producing bacteria at intensive care unit (ICU) admission, we conducted a prospective study of a 3.5-year cohort of patients admitted to medical and surgical ICUs at the University of Maryland Medical Center. Over the study period, admission cultures were obtained from 5,209 patients. Of these, 117 were colonized with ESBL-producing Escherichia coli and Klebsiella spp., and 29 (25%) had a subsequent ESBL-positive clinical culture. Multivariable analysis showed the following to be statistically associated with ESBL colonization at admission: piperacillin-tazobactam (odds ratio [OR] 2.05, 95% confidence interval [CI] 1.36-3.10), vancomycin (OR 2.11, 95% CI 1.34-3.31), age > 60 years (OR 1.79, 95% CI 1.24-2.60), and chronic disease score (OR 1.15; 95% CI 1.04-1.27). Coexisting conditions and previous antimicrobial drug exposure are thus predictive of colonization, and a large percentage of these patients have subsequent positive clinical cultures for ESBL-producing bacteria.
Subject:
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Aged
Beta-Lactamases
Beta-Lactam Resistance
Beta Lactamases
Cohort Studies
Cross-Sectional Studies
Drug-resistance Microbial
Drug Resistance, Multiple, Bacterial
Escherichia Coli
Escherichia Coli Infections
Female
Humans
Intensive Care Units
Klebsiella
Klebsiella Infections
Male
Microbial Sensitivity Tests
Middle Aged
Prospective Studies
Research
Risk Factors
Intensive Care Units
Research

Source:
Emerg Infect Dis. 13(8):1144-1149.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:cbe43724df7c200c3bed545108fa1a40699a8bf53323fb1659bb3ddb827085ae
File Type:

Supporting Files

• 	07-0071_finalR.nxml	txt
  	license.txt	txt

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