Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Schneider-Lindner, Verena ; Delaney, J. A. ; Dial, Sandra ; Dascal, Andre ; Suissa, Samy
• Description:
  We report results of a case-control study of the association between receipt of antimicrobial agents and diagnosis of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in the United Kingdom. Eligible adults, selected from the General Practice Research Database, had no previous diagnosis of MRSA, no hospitalization in the past 2 years, and > or = 2 years of follow-up recorded in the database. For 2000-2004, we identified 1,981 MRSA case-patients and 19,779 matched control-patients. The odds ratios (ORs) and 95% confidence intervals (CIs) of MRSA diagnosis for patients who were prescribed 1, 2-3, or > or = 4 antimicrobial drugs were 1.57 (CI 1.36-1.80), 2.46 (CI 2.15-2.83), and 6.24 (CI 5.43-7.17), respectively. Risk for community-acquired MRSA increased with number of antimicrobial drug prescriptions, appeared to vary according to antimicrobial drug classes prescribed the previous year, and was highest for quinolones (OR 3.37, CI 2.80-4.09) and macrolides (OR 2.50, CI 2.14-2.91).
• Subjects:
  • Research
  • Methicillin-resistant Staphylococcus aureus
  • general practice research database
  • antimicrobial agents
  • epidemiology
  • case-control study
  • pharmacoepidemiology
  • risk factors
  • infectious disease
  • research
  More +
• Source:
  Emerg Infect Dis. 13(7):994-1000.
• Document Type:
  Journal Article
• Volume:
  13
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/16653/cdc_16653_DS1.pdf
• File Type:
  [PDF - 276.09 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:013b365621d3304e8f2b899ce74e26107ba71f6e480a48951a777823e1c77a1d