Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom

Schneider-Lindner, Verena; Delaney, J. A.; Dial, Sandra; Dascal, Andre; Suissa, Samy

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Antimicrobial Drugs and Community-acquired Methicillin-Resistant Staphylococcus aureus, United Kingdom

Supporting Files Public Domain

Jul 2007
By Schneider-Lindner, Verena ; Delaney, J. A. ; Dial, Sandra ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Schneider-Lindner, Verena ; Delaney, J. A. ; Dial, Sandra ; Dascal, Andre ; Suissa, Samy
Description:

We report results of a case-control study of the association between receipt of antimicrobial agents and diagnosis of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in the United Kingdom. Eligible adults, selected from the General Practice Research Database, had no previous diagnosis of MRSA, no hospitalization in the past 2 years, and > or = 2 years of follow-up recorded in the database. For 2000-2004, we identified 1,981 MRSA case-patients and 19,779 matched control-patients. The odds ratios (ORs) and 95% confidence intervals (CIs) of MRSA diagnosis for patients who were prescribed 1, 2-3, or > or = 4 antimicrobial drugs were 1.57 (CI 1.36-1.80), 2.46 (CI 2.15-2.83), and 6.24 (CI 5.43-7.17), respectively. Risk for community-acquired MRSA increased with number of antimicrobial drug prescriptions, appeared to vary according to antimicrobial drug classes prescribed the previous year, and was highest for quinolones (OR 3.37, CI 2.80-4.09) and macrolides (OR 2.50, CI 2.14-2.91).
Subjects:

Aged Anti-Bacterial Agents Antimicrobial Agents Case-Control Studies Case-control Study Colony Count, Microbial Community-Acquired Infections Confidence Intervals Drug Resistance, Bacterial Epidemiology Female General Practice Research Database Great Britain Humans Infectious Disease Male Methicillin Methicillin Resistance Microbial Sensitivity Tests Odds Ratio Pharmacoepidemiology Research Retrospective Studies Risk Assessment Risk Factors Staphylococcal Infections Staphylococcus Aureus
Source:

Emerg Infect Dis. 13(7):994-1000.
Document Type:

Journal Article
Volume:

13
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:013b365621d3304e8f2b899ce74e26107ba71f6e480a48951a777823e1c77a1d
Download URL:

https://stacks.cdc.gov/view/cdc/16653/cdc_16653_DS1.pdf
File Type:

[PDF - 276.09 KB ]

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