Global Emergence of Trimethoprim/Sulfamethoxazole Resistance in Stenotrophomonas maltophilia Mediated by Acquisition of sul Genes

Toleman, Mark A.; Bennett, Peter M.; Bennett, David M.C.; Jones, Ronald N.; Walsh, Timothy R.

doi:10.3201/eid1304.061378

i

Global Emergence of Trimethoprim/Sulfamethoxazole Resistance in Stenotrophomonas maltophilia Mediated by Acquisition of sul Genes

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Apr 2007
By Toleman, Mark A. ; Bennett, Peter M. ; Bennett, David M.C. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Toleman, Mark A. ; Bennett, Peter M. ; Bennett, David M.C. ; Jones, Ronald N. ; Walsh, Timothy R.
Description:

Trimethoprim/sulfamethoxazole (TMP/SMX) resistance remains a serious threat in the treatment of Stenotrophomonas maltophilia infections. We analyzed an international collection of 55 S. maltophilia TMP/SMX-sensitive (S) (n=30) and -resistant (R) (n=25) strains for integrons; sul1, sul2 and dhfr genes; and insertion element common region (ISCR) elements. sul1, as part of a class 1 integron, was detected in 17 of 25 TMP/SMX-R. Nine TMP/SMX-R strains carried sul2; 7 were on large plasmids. Five TMP/SMX-R isolates were positive for ISCR2, and 4 were linked to sul2; 2 others possessed ISCR3. Two ISCR2s were adjacent to floR. Six TMP/SMX-S isolates harbored novel ISCR elements, ISCR9 and ISCR10. Linkage of ISCR3, ISCR9, and ISCR10 to sul2 and dhfr genes was not demonstrated. The data from this study indicate that class 1 integrons and ISCR elements linked to sul2 genes can mediate TMP/SMX resistance in S. maltophilia and are geographically widespread, findings that reinforce the need for ongoing resistance surveillance.
Subjects:

Anti-Bacterial Agents Bacterial Proteins Carrier Proteins Common Regions DNA Transposable Elements Drug Resistance, Bacterial Gram-Negative Bacterial Infections Humans Integrons ISCR Microbial Sensitivity Tests Molecular Sequence Data Research Resistance Sequence Analysis, DNA Stenotrophomonas Maltophilia Sul Genes Trimethoprim Trimethoprim Resistance
Source:

Emerg Infect Dis. 13(4):559-565.
Document Type:

Journal Article
Volume:

13
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:ba814264353afea1111d020562e79c9d57dd36fc67f6ec60637ad39b0b150ad7
Download URL:

https://stacks.cdc.gov/view/cdc/16604/cdc_16604_DS1.pdf
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[PDF - 162.80 KB ]

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