Confronting Potential Influenza A (H5N1) Pandemic with Better Vaccines

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Haque, Azizul ; Hober, Didier ; Kasper, Lloyd H.
• Description:
  Influenza A (H5N1) viruses are strong candidates for causing the next influenza pandemic if they acquire the ability for efficient human-to-human transmission. A major public health goal is to make efficacious vaccines against these viruses by using novel approaches, including cell-culture system, reverse genetics, and adjuvant development. Important consideration for the strategy includes preparation of vaccines from a currently circulating strain to induce broad-spectrum immunity toward newly emerged human H5 strains. This strategy would be a good solution early in a pandemic until an antigenically matched and approved vaccine is produced. The concept of therapeutic vaccines (e.g., antidisease vaccine) directed at diminishing the cytokine storm frequently seen in subtype H5N1-infected persons is underscored. Better understanding of host-virus interaction is essential to identify tools to produce effective vaccines against influenza (H5N1).
• Subjects:
  • Perspective
  • Animals
  • Disease Outbreaks
  • Humans
  • Influenza A Virus, H5N1 Subtype
  • Influenza Vaccines
  • Influenza in Birds
  • Influenza, Human
  • Poultry
  • Vaccines, Attenuated
  More +
• Source:
  Emerg Infect Dis. 13(10):1512-1518.
• Document Type:
  Journal Article
• Volume:
  13
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/16567/cdc_16567_DS1.pdf
• File Type:
  [PDF - 195.65 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9078e38f2ddb72ab3a286831e60f78e5645ea6244a4b49d6bc79a5229c97e287