Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1

Tompkins, Stephen Mark; Zhao, Zi-Shan; Lo, Chia-Yun; Misplon, Julia A.; Liu, Teresa; Ye, Zhiping; Hogan, Robert J.; Wu, Zhengqi; Benton, Kimberly A.; Tumpey, Terrence M.; Epstein, Suzanne L.

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Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1

Supporting Files Public Domain

Mar 2007
By Tompkins, Stephen Mark ; Zhao, Zi-Shan ; Lo, Chia-Yun

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Alternative Title:

Emerg Infect Dis
Personal Author:

Tompkins, Stephen Mark ; Zhao, Zi-Shan ; Lo, Chia-Yun ; Misplon, Julia A. ; Liu, Teresa ; Ye, Zhiping ; Hogan, Robert J. ; Wu, Zhengqi ; Benton, Kimberly A. ; Tumpey, Terrence M. ; Epstein, Suzanne L.
Description:

Changes in influenza viruses require regular reformulation of strain-specific influenza vaccines. Vaccines based on conserved antigens provide broader protection. Influenza matrix protein 2 (M2) is highly conserved across influenza A subtypes. To evaluate its efficacy as a vaccine candidate, we vaccinated mice with M2 peptide of a widely shared consensus sequence. This vaccination induced antibodies that cross-reacted with divergent M2 peptide from an H5N1 subtype. A DNA vaccine expressing full-length consensus-sequence M2 (M2-DNA) induced M2-specific antibody responses and protected against challenge with lethal influenza. Mice primed with M2-DNA and then boosted with recombinant adenovirus expressing M2 (M2-Ad) had enhanced antibody responses that crossreacted with human and avian M2 sequences and produced T-cell responses. This M2 prime-boost vaccination conferred broad protection against challenge with lethal influenza A, including an H5N1 strain. Vaccination with M2, with key sequences represented, may provide broad protection against influenza A.
Subjects:
Source:

Emerg Infect Dis. 13(3):426-435.
Document Type:

Journal Article
Volume:

13
Issue:

3
Download URL:

https://stacks.cdc.gov/view/cdc/16535/cdc_16535_DS1.pdf
File Type:

[PDF - 430.68 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:f5eab70db0a73c96fb4b9bf2dfd3af503c6f1377fa4e7a219a5fa9e4418adb1b

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