Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Gavidia, Cesar M. ; Gonzalez, Armando E. ; Zhang, Wenbao ; McManus, Donald P. ; Lopera, Luis ; Ninaquispe, Berenice ; Garcia, Hector H. ; Rodríguez, Silvia ; Verastegui, Manuela ; Calderon, Carmen ; Pan, William K.Y. ; Gilman, Robert H.
• Description:
  We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field.
• Subjects:
  Adult Animals Antibodies, Helminth Antigens, Helminth Child, Preschool Echinococcosis, Hepatic Echinococcosis, Pulmonary Echinococcus Endemic Diseases Female Humans Immunoblotting Liver Lung Male Prevalence Rural Population

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• Source:
  Emerg Infect Dis. 14(2):260-266.
• Document Type:
  Journal Article
• Place as Subject:
  Peru
• Volume:
  14
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f5d788e797a35f1b5e1e9b8efd3b50eefae63477225950f475bc95446ec2f0b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/16527/cdc_16527_DS1.pdf
• File Type:
  [PDF - 270.78 KB ]